| http://purl.uniprot.org/citations/12527895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12527895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12527895 | http://www.w3.org/2000/01/rdf-schema#comment | "Src-like adaptor protein 2 (SLAP-2) is a recently characterized adaptor protein bearing sequence and structural similarity to the Src-like adaptor protein (SLAP). SLAP-2 expression is hematopoietic-specific, and it has been demonstrated to function as a negative regulator of T-cell antigen receptor (TCR)-mediated signalling by virtue of its interaction with c-Cbl. Here we report the cloning of a cDNA encoding the human homologue of SLAP-2, as well as the genomic structure of the human SLAP-2 gene. Similar to its murine counterpart, two human SLAP-2 protein isoforms exist because of alternative translation initiation, and SLAP-2 protein expression is observed in a variety of hematopoietic cell lines of both lymphoid and myeloid lineages. The human SLAP-2 gene is located on chromosome 20q, and the SLAP-2 coding region consists of seven exons. Concurrent with the cloning of the full-length SLAP-2 cDNA, a unique cDNA encoding an alternatively spliced SLAP-2 isoform has been identified, and designated as SLAP-2-v. The SLAP-2-v transcript encodes a putative protein of 210 amino acids that lacks the c-Cbl interaction region, and consequently is impaired in its ability to both bind to c-Cbl, and inhibit TCR signalling relative to SLAP-2."xsd:string |
| http://purl.uniprot.org/citations/12527895 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1206114"xsd:string |
| http://purl.uniprot.org/citations/12527895 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1206114"xsd:string |
| http://purl.uniprot.org/citations/12527895 | http://purl.uniprot.org/core/author | "McGlade C.J."xsd:string |
| http://purl.uniprot.org/citations/12527895 | http://purl.uniprot.org/core/author | "McGlade C.J."xsd:string |
| http://purl.uniprot.org/citations/12527895 | http://purl.uniprot.org/core/author | "Loreto M.P."xsd:string |
| http://purl.uniprot.org/citations/12527895 | http://purl.uniprot.org/core/author | "Loreto M.P."xsd:string |
| http://purl.uniprot.org/citations/12527895 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12527895 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12527895 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/12527895 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/12527895 | http://purl.uniprot.org/core/pages | "266-273"xsd:string |
| http://purl.uniprot.org/citations/12527895 | http://purl.uniprot.org/core/pages | "266-273"xsd:string |
| http://purl.uniprot.org/citations/12527895 | http://purl.uniprot.org/core/title | "Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v."xsd:string |
| http://purl.uniprot.org/citations/12527895 | http://purl.uniprot.org/core/title | "Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v."xsd:string |
| http://purl.uniprot.org/citations/12527895 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12527895 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12527895 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12527895 |
| http://purl.uniprot.org/citations/12527895 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12527895 |
| http://purl.uniprot.org/citations/12527895 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12527895 |
| http://purl.uniprot.org/citations/12527895 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12527895 |
| http://purl.uniprot.org/uniprot/Q9H6Q3 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12527895 |
| http://purl.uniprot.org/uniprot/#_kb.Q9H6Q3_up.isolatedFrom_tissue.1043 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12527895 |