| http://purl.uniprot.org/citations/12527908 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12527908 | http://www.w3.org/2000/01/rdf-schema#comment | "TEL belongs to a member of the ETS family transcription factors that represses transcription of target genes such as FLI-1. Although TEL is essential for establishing hematopoiesis in neonatal bone marrow, its role in erythroid lineage is not understood. To investigate a role for TEL in erythroid differentiation, we introduced TEL into mouse erythroleukemia (MEL) cells. Overexpressing wild-type-TEL in MEL cells enhanced differentiation induced by hexamethylene bisacetamide or dimethylsulfoxide, as judged by the increased levels of erythroid-specific delta-aminolevulinate synthase and beta-globin mRNAs. TEL bound to a corepressor mSin3A through the helix-loop-helix domain. A TEL mutant lacking this domain still bound to the ETS binding site, but lost its transrepressional effect. This mutant completely blocked erythroid differentiation in MEL cells. Moreover, it showed dominant-negative effects over TEL-mediated transcriptional repression and acceleration of erythroid differentiation. Endogenous TEL mRNA was found to increase during the first 3 days in differentiating MEL cells and drastically decrease thereafter. All these data suggest that TEL might play some role in erythroid cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/12527908 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1206072"xsd:string |
| http://purl.uniprot.org/citations/12527908 | http://purl.uniprot.org/core/author | "Arai H."xsd:string |
| http://purl.uniprot.org/citations/12527908 | http://purl.uniprot.org/core/author | "Hirai H."xsd:string |
| http://purl.uniprot.org/citations/12527908 | http://purl.uniprot.org/core/author | "Mitani K."xsd:string |
| http://purl.uniprot.org/citations/12527908 | http://purl.uniprot.org/core/author | "Nakamura Y."xsd:string |
| http://purl.uniprot.org/citations/12527908 | http://purl.uniprot.org/core/author | "Yamagata T."xsd:string |
| http://purl.uniprot.org/citations/12527908 | http://purl.uniprot.org/core/author | "Sasaki K."xsd:string |
| http://purl.uniprot.org/citations/12527908 | http://purl.uniprot.org/core/author | "Maki K."xsd:string |
| http://purl.uniprot.org/citations/12527908 | http://purl.uniprot.org/core/author | "Kurokawa M."xsd:string |
| http://purl.uniprot.org/citations/12527908 | http://purl.uniprot.org/core/author | "Waga K."xsd:string |
| http://purl.uniprot.org/citations/12527908 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12527908 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/12527908 | http://purl.uniprot.org/core/pages | "59-68"xsd:string |
| http://purl.uniprot.org/citations/12527908 | http://purl.uniprot.org/core/title | "Leukemia-related transcription factor TEL accelerates differentiation of Friend erythroleukemia cells."xsd:string |
| http://purl.uniprot.org/citations/12527908 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12527908 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12527908 |
| http://purl.uniprot.org/citations/12527908 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12527908 |
| http://purl.uniprot.org/uniprot/P97360#attribution-DE327E4B5D0E6ADA520BB337A8B09DDF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12527908 |
| http://purl.uniprot.org/uniprot/P26323#attribution-DE327E4B5D0E6ADA520BB337A8B09DDF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12527908 |
| http://purl.uniprot.org/uniprot/#_E9QAJ7-mappedCitation-12527908 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12527908 |
| http://purl.uniprot.org/uniprot/#_E9Q2L1-mappedCitation-12527908 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12527908 |
| http://purl.uniprot.org/uniprot/#_E9Q8J8-mappedCitation-12527908 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12527908 |
| http://purl.uniprot.org/uniprot/#_E9PXF9-mappedCitation-12527908 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12527908 |