| http://purl.uniprot.org/citations/12529173 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12529173 | http://www.w3.org/2000/01/rdf-schema#comment | "Fn14 is a growth-factor-inducible immediate-early-response gene encoding a 102-amino-acid type I transmembrane protein. The human Fn14 protein was recently identified as a cell-surface receptor for the tumour necrosis factor (TNF) superfamily member named TWEAK (TNF-like weak inducer of apoptosis). In the present paper, we report that the human TWEAK extracellular domain can also bind the murine Fn14 protein. Furthermore, site-specific mutagenesis and directed yeast two-hybrid interaction assays revealed that the TNFR-associated factor (TRAF) 1, 2, 3 and 5 adaptor molecules bind the murine Fn14 cytoplasmic tail at an overlapping, but non-identical, amino acid sequence motif. We also found that TWEAK treatment of quiescent NIH 3T3 cells stimulates inhibitory kappaBalpha phosphorylation and transcriptional activation of a nuclear factor-kappaB (NF-kappaB) enhancer/luciferase reporter construct. Fn14 overexpression in transiently transfected NIH 3T3 cells also promotes NF-kappaB activation, and this cellular response requires an intact TRAF binding site. These results indicate that Fn14 is a functional TWEAK receptor that can associate with four distinct TRAF family members and stimulate the NF-kappaB transcription factor signalling pathway."xsd:string |
| http://purl.uniprot.org/citations/12529173 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20021730"xsd:string |
| http://purl.uniprot.org/citations/12529173 | http://purl.uniprot.org/core/author | "Richards C.M."xsd:string |
| http://purl.uniprot.org/citations/12529173 | http://purl.uniprot.org/core/author | "Winkles J.A."xsd:string |
| http://purl.uniprot.org/citations/12529173 | http://purl.uniprot.org/core/author | "Brown S.A."xsd:string |
| http://purl.uniprot.org/citations/12529173 | http://purl.uniprot.org/core/author | "Feng S.L."xsd:string |
| http://purl.uniprot.org/citations/12529173 | http://purl.uniprot.org/core/author | "Hanscom H.N."xsd:string |
| http://purl.uniprot.org/citations/12529173 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12529173 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/12529173 | http://purl.uniprot.org/core/pages | "395-403"xsd:string |
| http://purl.uniprot.org/citations/12529173 | http://purl.uniprot.org/core/title | "The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation."xsd:string |
| http://purl.uniprot.org/citations/12529173 | http://purl.uniprot.org/core/volume | "371"xsd:string |
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