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| http://purl.uniprot.org/citations/12529385 | http://www.w3.org/2000/01/rdf-schema#comment | "Mouse Hus1 encodes an evolutionarily conserved DNA damage response protein. In this study we examined how targeted deletion of Hus1 affects cell cycle checkpoint responses to genotoxic stress. Unlike hus1(-) fission yeast (Schizosaccharomyces pombe) cells, which are defective for the G(2)/M DNA damage checkpoint, Hus1-null mouse cells did not inappropriately enter mitosis following genotoxin treatment. However, Hus1-deficient cells displayed a striking S-phase DNA damage checkpoint defect. Whereas wild-type cells transiently repressed DNA replication in response to benzo(a)pyrene dihydrodiol epoxide (BPDE), a genotoxin that causes bulky DNA adducts, Hus1-null cells maintained relatively high levels of DNA synthesis following treatment with this agent. However, when treated with DNA strand break-inducing agents such as ionizing radiation (IR), Hus1-deficient cells showed intact S-phase checkpoint responses. Conversely, checkpoint-mediated inhibition of DNA synthesis in response to BPDE did not require NBS1, a component of the IR-responsive S-phase checkpoint pathway. Taken together, these results demonstrate that Hus1 is required specifically for one of two separable mammalian checkpoint pathways that respond to distinct forms of genome damage during S phase."xsd:string |
| http://purl.uniprot.org/citations/12529385 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.23.3.791-803.2003"xsd:string |
| http://purl.uniprot.org/citations/12529385 | http://purl.uniprot.org/core/author | "Leder P."xsd:string |
| http://purl.uniprot.org/citations/12529385 | http://purl.uniprot.org/core/author | "Weiss R.S."xsd:string |
| http://purl.uniprot.org/citations/12529385 | http://purl.uniprot.org/core/author | "Vaziri C."xsd:string |
| http://purl.uniprot.org/citations/12529385 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12529385 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/12529385 | http://purl.uniprot.org/core/pages | "791-803"xsd:string |
| http://purl.uniprot.org/citations/12529385 | http://purl.uniprot.org/core/title | "Critical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpoint."xsd:string |
| http://purl.uniprot.org/citations/12529385 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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