| http://purl.uniprot.org/citations/12529430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12529430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12529430 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein phosphatase 1 (PP1) is a ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. When transiently expressed as fluorescent protein (FP) fusions, the three PP1 isoforms, alpha, beta/delta, and gamma1, are active phosphatases with distinct localization patterns. We report here the establishment and characterization of HeLa cell lines stably expressing either FP-PP1gamma or FP alone. Time-lapse imaging reveals dynamic targeting of FP-PP1gamma to specific sites throughout the cell cycle, contrasting with the diffuse pattern observed for FP alone. FP-PP1gamma shows a nucleolar accumulation during interphase. On entry into mitosis, it localizes initially at kinetochores, where it exchanges rapidly with the diffuse cytoplasmic pool. A dramatic relocalization of PP1 to the chromosome-containing regions occurs at the transition from early to late anaphase, and by telophase FP-PP1gamma also accumulates at the cleavage furrow and midbody. The changing spatio-temporal distribution of PP1gamma revealed using the stable PP1 cell lines implicates it in multiple processes, including nucleolar function, the regulation of chromosome segregation and cytokinesis."xsd:string |
| http://purl.uniprot.org/citations/12529430 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e02-07-0376"xsd:string |
| http://purl.uniprot.org/citations/12529430 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e02-07-0376"xsd:string |
| http://purl.uniprot.org/citations/12529430 | http://purl.uniprot.org/core/author | "Lam Y.W."xsd:string |
| http://purl.uniprot.org/citations/12529430 | http://purl.uniprot.org/core/author | "Lam Y.W."xsd:string |
| http://purl.uniprot.org/citations/12529430 | http://purl.uniprot.org/core/author | "Andrews P.D."xsd:string |
| http://purl.uniprot.org/citations/12529430 | http://purl.uniprot.org/core/author | "Andrews P.D."xsd:string |
| http://purl.uniprot.org/citations/12529430 | http://purl.uniprot.org/core/author | "Prescott A."xsd:string |
| http://purl.uniprot.org/citations/12529430 | http://purl.uniprot.org/core/author | "Prescott A."xsd:string |
| http://purl.uniprot.org/citations/12529430 | http://purl.uniprot.org/core/author | "Lamond A.I."xsd:string |
| http://purl.uniprot.org/citations/12529430 | http://purl.uniprot.org/core/author | "Lamond A.I."xsd:string |
| http://purl.uniprot.org/citations/12529430 | http://purl.uniprot.org/core/author | "Swedlow J.R."xsd:string |
| http://purl.uniprot.org/citations/12529430 | http://purl.uniprot.org/core/author | "Swedlow J.R."xsd:string |
| http://purl.uniprot.org/citations/12529430 | http://purl.uniprot.org/core/author | "Sleeman J."xsd:string |
| http://purl.uniprot.org/citations/12529430 | http://purl.uniprot.org/core/author | "Sleeman J."xsd:string |
| http://purl.uniprot.org/citations/12529430 | http://purl.uniprot.org/core/author | "Trinkle-Mulcahy L."xsd:string |
| http://purl.uniprot.org/citations/12529430 | http://purl.uniprot.org/core/author | "Trinkle-Mulcahy L."xsd:string |
| http://purl.uniprot.org/citations/12529430 | http://purl.uniprot.org/core/author | "Lyon C."xsd:string |
| http://purl.uniprot.org/citations/12529430 | http://purl.uniprot.org/core/author | "Lyon C."xsd:string |
| http://purl.uniprot.org/citations/12529430 | http://purl.uniprot.org/core/author | "Wickramasinghe S."xsd:string |
| http://purl.uniprot.org/citations/12529430 | http://purl.uniprot.org/core/author | "Wickramasinghe S."xsd:string |
| http://purl.uniprot.org/citations/12529430 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12529430 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |