Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/12530079http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12530079http://www.w3.org/2000/01/rdf-schema#comment"

Background

The maintenance of telomeres may be required for long-term proliferation of tumors. Activity of telomerase, a ribonucleoprotein complex that elongates telomeres, has been found in almost all human tumors but not in adjacent normal cells. Several factors which regulate telomere length, TRF1 and 2, TIN2, tankyrase and Rap1, have been identified. TRF1, TRF2 and TIN2 are negative regulators of telomere length, while tankyrase and Rap1 act as positive regulators. In this study, we quantitated the mRNA of these five genes in gastric cancers to clarify the mechanism by which cancer cells maintain telomere length.

Materials and methods

The expression of these five genes transcription was determined using a quantitative RT-PCR.

Results

TRF1, TRF2 and TIN2 mRNAs were significantly down-regulated in cancers compared to non-cancerous mucosa. Neither tankyrase nor Rap1 was upregulated in cancers.

Conclusion

Down-regulation of TRF1, TRF2 and TIN2 gene expression may be important to maintain telomeres in gastric cancer."xsd:string
http://purl.uniprot.org/citations/12530079http://purl.uniprot.org/core/author"Nakamura M."xsd:string
http://purl.uniprot.org/citations/12530079http://purl.uniprot.org/core/author"Yamada M."xsd:string
http://purl.uniprot.org/citations/12530079http://purl.uniprot.org/core/author"Watanabe N."xsd:string
http://purl.uniprot.org/citations/12530079http://purl.uniprot.org/core/author"Tsuji N."xsd:string
http://purl.uniprot.org/citations/12530079http://purl.uniprot.org/core/author"Kobayashi D."xsd:string
http://purl.uniprot.org/citations/12530079http://purl.uniprot.org/core/author"Yagihashi A."xsd:string
http://purl.uniprot.org/citations/12530079http://purl.uniprot.org/core/author"Moriai R."xsd:string
http://purl.uniprot.org/citations/12530079http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/12530079http://purl.uniprot.org/core/name"Anticancer Res"xsd:string
http://purl.uniprot.org/citations/12530079http://purl.uniprot.org/core/pages"3303-3307"xsd:string
http://purl.uniprot.org/citations/12530079http://purl.uniprot.org/core/title"Down-regulation of TRF1, TRF2 and TIN2 genes is important to maintain telomeric DNA for gastric cancers."xsd:string
http://purl.uniprot.org/citations/12530079http://purl.uniprot.org/core/volume"22"xsd:string
http://purl.uniprot.org/citations/12530079http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12530079
http://purl.uniprot.org/citations/12530079http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12530079
http://purl.uniprot.org/uniprot/#_P54274-mappedCitation-12530079http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12530079
http://purl.uniprot.org/uniprot/#_Q15554-mappedCitation-12530079http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12530079
http://purl.uniprot.org/uniprot/#_B4DFJ1-mappedCitation-12530079http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12530079
http://purl.uniprot.org/uniprot/#_A8K914-mappedCitation-12530079http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12530079
http://purl.uniprot.org/uniprot/#_Q5QGN5-mappedCitation-12530079http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12530079
http://purl.uniprot.org/uniprot/#_H0YL20-mappedCitation-12530079http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12530079
http://purl.uniprot.org/uniprot/#_Q86TZ8-mappedCitation-12530079http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12530079
http://purl.uniprot.org/uniprot/#_Q9BSI4-mappedCitation-12530079http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12530079
http://purl.uniprot.org/uniprot/A8K914http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/12530079
▶