| http://purl.uniprot.org/citations/12530969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12530969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12530969 | http://www.w3.org/2000/01/rdf-schema#comment | "To gain insights into the genetic cascades that regulate fat biology, we evaluated C. elegans as an appropriate model organism. We generated worms that lack two transcription factors, SREBP and C/EBP, crucial for formation of mammalian fat. Worms deficient in either of these genes displayed a lipid-depleted phenotype-pale, skinny, larval-arrested worms that lack fat stores. On the basis of this phenotype, we used a reverse genetic screen to identify several additional genes that play a role in worm lipid storage. Two of the genes encode components of the mitochondrial respiratory chain (MRC). When the MRC was inhibited chemically in worms or in a mammalian adipocyte model, fat accumulation was markedly reduced. A third encodes lpd-3, whose homolog is also required for fat storage in a mammalian model. These data suggest that C. elegans is a genetically tractable model to study the mechanisms that underlie the biology of fat-storing tissues."xsd:string |
| http://purl.uniprot.org/citations/12530969 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1534-5807(02)00411-2"xsd:string |
| http://purl.uniprot.org/citations/12530969 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1534-5807(02)00411-2"xsd:string |
| http://purl.uniprot.org/citations/12530969 | http://purl.uniprot.org/core/author | "Avery L."xsd:string |
| http://purl.uniprot.org/citations/12530969 | http://purl.uniprot.org/core/author | "Avery L."xsd:string |
| http://purl.uniprot.org/citations/12530969 | http://purl.uniprot.org/core/author | "McKay J.P."xsd:string |
| http://purl.uniprot.org/citations/12530969 | http://purl.uniprot.org/core/author | "McKay J.P."xsd:string |
| http://purl.uniprot.org/citations/12530969 | http://purl.uniprot.org/core/author | "McKay R.M."xsd:string |
| http://purl.uniprot.org/citations/12530969 | http://purl.uniprot.org/core/author | "McKay R.M."xsd:string |
| http://purl.uniprot.org/citations/12530969 | http://purl.uniprot.org/core/author | "Graff J.M."xsd:string |
| http://purl.uniprot.org/citations/12530969 | http://purl.uniprot.org/core/author | "Graff J.M."xsd:string |
| http://purl.uniprot.org/citations/12530969 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12530969 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12530969 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/12530969 | http://purl.uniprot.org/core/name | "Dev. Cell"xsd:string |
| http://purl.uniprot.org/citations/12530969 | http://purl.uniprot.org/core/pages | "131-142"xsd:string |
| http://purl.uniprot.org/citations/12530969 | http://purl.uniprot.org/core/pages | "131-142"xsd:string |
| http://purl.uniprot.org/citations/12530969 | http://purl.uniprot.org/core/title | "C elegans: a model for exploring the genetics of fat storage."xsd:string |
| http://purl.uniprot.org/citations/12530969 | http://purl.uniprot.org/core/title | "C elegans: a model for exploring the genetics of fat storage."xsd:string |
| http://purl.uniprot.org/citations/12530969 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/12530969 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/12530969 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12530969 |
| http://purl.uniprot.org/citations/12530969 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12530969 |