| http://purl.uniprot.org/citations/12530983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12530983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12530983 | http://www.w3.org/2000/01/rdf-schema#comment | "The Wiskott-Aldrich syndrome protein (WASp) couples actin cytoskeletal rearrangement to T cell activation, but the mechanisms involved are unknown. Here, we show that antigen-induced formation of T cell:APC conjugates and synapses is abrogated in WASp-deficient T cells and that CD2 engagement evokes interactions between the proline-rich region required for WASp translocation to the synapse and the PSTPIP1 adaptor SH3 domain and between the PSTPIp1 coiled-coil domain and both CD2 and another CD2-binding adaptor, CD2AP. The induced colocalization of these proteins at the synapse is disrupted by expression of coiled-coil domain-deleted PSTPIP1. These data, together with the impairment in CD2-induced actin polymerization observed in WASp-deficient cells, suggest that PSTPIP1 acts downstream of CD2/CD2AP to link CD2 engagement to the WASp-evoked actin polymerization required for synapse formation and T cell activation."xsd:string |
| http://purl.uniprot.org/citations/12530983 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1074-7613(02)00516-2"xsd:string |
| http://purl.uniprot.org/citations/12530983 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1074-7613(02)00516-2"xsd:string |
| http://purl.uniprot.org/citations/12530983 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/12530983 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/12530983 | http://purl.uniprot.org/core/author | "Field D."xsd:string |
| http://purl.uniprot.org/citations/12530983 | http://purl.uniprot.org/core/author | "Field D."xsd:string |
| http://purl.uniprot.org/citations/12530983 | http://purl.uniprot.org/core/author | "Siminovitch K.A."xsd:string |
| http://purl.uniprot.org/citations/12530983 | http://purl.uniprot.org/core/author | "Siminovitch K.A."xsd:string |
| http://purl.uniprot.org/citations/12530983 | http://purl.uniprot.org/core/author | "Shi F."xsd:string |
| http://purl.uniprot.org/citations/12530983 | http://purl.uniprot.org/core/author | "Shi F."xsd:string |
| http://purl.uniprot.org/citations/12530983 | http://purl.uniprot.org/core/author | "Badour K."xsd:string |
| http://purl.uniprot.org/citations/12530983 | http://purl.uniprot.org/core/author | "Badour K."xsd:string |
| http://purl.uniprot.org/citations/12530983 | http://purl.uniprot.org/core/author | "Hardy L.A."xsd:string |
| http://purl.uniprot.org/citations/12530983 | http://purl.uniprot.org/core/author | "Hardy L.A."xsd:string |
| http://purl.uniprot.org/citations/12530983 | http://purl.uniprot.org/core/author | "McGavin M.K.H."xsd:string |
| http://purl.uniprot.org/citations/12530983 | http://purl.uniprot.org/core/author | "McGavin M.K.H."xsd:string |
| http://purl.uniprot.org/citations/12530983 | http://purl.uniprot.org/core/author | "Rampersad V."xsd:string |
| http://purl.uniprot.org/citations/12530983 | http://purl.uniprot.org/core/author | "Rampersad V."xsd:string |
| http://purl.uniprot.org/citations/12530983 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12530983 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12530983 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/12530983 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |