| http://purl.uniprot.org/citations/12531529 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12531529 | http://www.w3.org/2000/01/rdf-schema#comment | "Various transcriptional activators are induced in neurons concomitantly with long-lasting neural activity, whereas only a few transcription factors are known to act as neural activity-inducible transcription repressors. In this study, mRNA of DREAM (DRE-antagonizing modulator), a Ca(2+)-modulated transcriptional repressor, was demonstrated to accumulate in the mouse brain after pentylenetetrazol (PTZ)-induced seizures. Accumulation in the mouse hippocampus reached maximal level in the late phase (at 7-8 h) after PTZ injection. Kainic acid induced the same response. Interestingly, the late induction of DREAM expression required new protein synthesis and was blocked by MK801 suggesting that Ca(2+)-influx via NMDA receptors is necessary for the PTZ-mediated DREAM expression. In situ hybridization revealed that PTZ-induced DREAM mRNA accumulation was observed particularly in the dentate gyrus, cerebral cortex, and piriform cortex. The results of the present study demonstrate that DREAM is a neural activity-stimulated late gene and suggest its involvement in adaptation to long-lasting neuronal activity."xsd:string |
| http://purl.uniprot.org/citations/12531529 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0169-328x(02)00562-4"xsd:string |
| http://purl.uniprot.org/citations/12531529 | http://purl.uniprot.org/core/author | "Aoki T."xsd:string |
| http://purl.uniprot.org/citations/12531529 | http://purl.uniprot.org/core/author | "Mikoshiba K."xsd:string |
| http://purl.uniprot.org/citations/12531529 | http://purl.uniprot.org/core/author | "Tamura T.A."xsd:string |
| http://purl.uniprot.org/citations/12531529 | http://purl.uniprot.org/core/author | "Konishi Y."xsd:string |
| http://purl.uniprot.org/citations/12531529 | http://purl.uniprot.org/core/author | "Naranjo J.R."xsd:string |
| http://purl.uniprot.org/citations/12531529 | http://purl.uniprot.org/core/author | "Matsu-ura T."xsd:string |
| http://purl.uniprot.org/citations/12531529 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12531529 | http://purl.uniprot.org/core/name | "Brain Res Mol Brain Res"xsd:string |
| http://purl.uniprot.org/citations/12531529 | http://purl.uniprot.org/core/pages | "198-206"xsd:string |
| http://purl.uniprot.org/citations/12531529 | http://purl.uniprot.org/core/title | "Seizure-mediated neuronal activation induces DREAM gene expression in the mouse brain."xsd:string |
| http://purl.uniprot.org/citations/12531529 | http://purl.uniprot.org/core/volume | "109"xsd:string |
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