| http://purl.uniprot.org/citations/12535524 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12535524 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12535524 | http://www.w3.org/2000/01/rdf-schema#comment | "Crystal structures of tRNA mimics complexed with the large ribosomal subunit of Deinococcus radiodurans indicate that remote interactions determine the precise orientation of tRNA in the peptidyl-transferase center (PTC). The PTC tolerates various orientations of puromycin derivatives and its flexibility allows the conformational rearrangements required for peptide-bond formation. Sparsomycin binds to A2602 and alters the PTC conformation. H69, the intersubunit-bridge connecting the PTC and decoding site, may also participate in tRNA placement and translocation. A spiral rotation of the 3' end of the A-site tRNA around a 2-fold axis of symmetry identified within the PTC suggests a unified ribosomal machinery for peptide-bond formation, A-to-P-site translocation, and entrance of nascent proteins into the exit tunnel. Similar 2-fold related regions, detected in all known structures of large ribosomal subunits, indicate the universality of this mechanism."xsd:string |
| http://purl.uniprot.org/citations/12535524 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(03)00009-1"xsd:string |
| http://purl.uniprot.org/citations/12535524 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(03)00009-1"xsd:string |
| http://purl.uniprot.org/citations/12535524 | http://purl.uniprot.org/core/author | "Zarivach R."xsd:string |
| http://purl.uniprot.org/citations/12535524 | http://purl.uniprot.org/core/author | "Zarivach R."xsd:string |
| http://purl.uniprot.org/citations/12535524 | http://purl.uniprot.org/core/author | "Berisio R."xsd:string |
| http://purl.uniprot.org/citations/12535524 | http://purl.uniprot.org/core/author | "Berisio R."xsd:string |
| http://purl.uniprot.org/citations/12535524 | http://purl.uniprot.org/core/author | "Franceschi F."xsd:string |
| http://purl.uniprot.org/citations/12535524 | http://purl.uniprot.org/core/author | "Franceschi F."xsd:string |
| http://purl.uniprot.org/citations/12535524 | http://purl.uniprot.org/core/author | "Hansen H.A."xsd:string |
| http://purl.uniprot.org/citations/12535524 | http://purl.uniprot.org/core/author | "Hansen H.A."xsd:string |
| http://purl.uniprot.org/citations/12535524 | http://purl.uniprot.org/core/author | "Yonath A."xsd:string |
| http://purl.uniprot.org/citations/12535524 | http://purl.uniprot.org/core/author | "Yonath A."xsd:string |
| http://purl.uniprot.org/citations/12535524 | http://purl.uniprot.org/core/author | "Auerbach T."xsd:string |
| http://purl.uniprot.org/citations/12535524 | http://purl.uniprot.org/core/author | "Auerbach T."xsd:string |
| http://purl.uniprot.org/citations/12535524 | http://purl.uniprot.org/core/author | "Bartels H."xsd:string |
| http://purl.uniprot.org/citations/12535524 | http://purl.uniprot.org/core/author | "Bartels H."xsd:string |
| http://purl.uniprot.org/citations/12535524 | http://purl.uniprot.org/core/author | "Bashan A."xsd:string |
| http://purl.uniprot.org/citations/12535524 | http://purl.uniprot.org/core/author | "Bashan A."xsd:string |
| http://purl.uniprot.org/citations/12535524 | http://purl.uniprot.org/core/author | "Harms J."xsd:string |
| http://purl.uniprot.org/citations/12535524 | http://purl.uniprot.org/core/author | "Harms J."xsd:string |
| http://purl.uniprot.org/citations/12535524 | http://purl.uniprot.org/core/author | "Schluenzen F."xsd:string |
| http://purl.uniprot.org/citations/12535524 | http://purl.uniprot.org/core/author | "Schluenzen F."xsd:string |