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http://purl.uniprot.org/citations/12535528http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12535528http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12535528http://www.w3.org/2000/01/rdf-schema#comment"LCoR (ligand-dependent corepressor) is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LXXLL motif. LCoR binding to estrogen receptor alpha depends in part on residues in the coactivator binding pocket distinct from those bound by TIF-2. Repression by LCoR is abolished by histone deacetylase inhibitor trichostatin A in a receptor-dependent fashion, indicating HDAC-dependent and -independent modes of action. LCoR binds directly to specific HDACs in vitro and in vivo. Moreover, LCoR functions by recruiting C-terminal binding protein corepressors through two consensus binding motifs and colocalizes with CtBPs in the nucleus. LCoR represents a class of corepressor that attenuates agonist-activated nuclear receptor signaling by multiple mechanisms."xsd:string
http://purl.uniprot.org/citations/12535528http://purl.org/dc/terms/identifier"doi:10.1016/s1097-2765(03)00014-5"xsd:string
http://purl.uniprot.org/citations/12535528http://purl.org/dc/terms/identifier"doi:10.1016/s1097-2765(03)00014-5"xsd:string
http://purl.uniprot.org/citations/12535528http://purl.uniprot.org/core/author"Lin R."xsd:string
http://purl.uniprot.org/citations/12535528http://purl.uniprot.org/core/author"Lin R."xsd:string
http://purl.uniprot.org/citations/12535528http://purl.uniprot.org/core/author"Lee H.S."xsd:string
http://purl.uniprot.org/citations/12535528http://purl.uniprot.org/core/author"Lee H.S."xsd:string
http://purl.uniprot.org/citations/12535528http://purl.uniprot.org/core/author"Mader S."xsd:string
http://purl.uniprot.org/citations/12535528http://purl.uniprot.org/core/author"Mader S."xsd:string
http://purl.uniprot.org/citations/12535528http://purl.uniprot.org/core/author"White J.H."xsd:string
http://purl.uniprot.org/citations/12535528http://purl.uniprot.org/core/author"White J.H."xsd:string
http://purl.uniprot.org/citations/12535528http://purl.uniprot.org/core/author"Eng F."xsd:string
http://purl.uniprot.org/citations/12535528http://purl.uniprot.org/core/author"Eng F."xsd:string
http://purl.uniprot.org/citations/12535528http://purl.uniprot.org/core/author"Cormier O."xsd:string
http://purl.uniprot.org/citations/12535528http://purl.uniprot.org/core/author"Cormier O."xsd:string
http://purl.uniprot.org/citations/12535528http://purl.uniprot.org/core/author"Yang X.-J."xsd:string
http://purl.uniprot.org/citations/12535528http://purl.uniprot.org/core/author"Yang X.-J."xsd:string
http://purl.uniprot.org/citations/12535528http://purl.uniprot.org/core/author"Pelletier N."xsd:string
http://purl.uniprot.org/citations/12535528http://purl.uniprot.org/core/author"Pelletier N."xsd:string
http://purl.uniprot.org/citations/12535528http://purl.uniprot.org/core/author"Bertos N.R."xsd:string
http://purl.uniprot.org/citations/12535528http://purl.uniprot.org/core/author"Bertos N.R."xsd:string
http://purl.uniprot.org/citations/12535528http://purl.uniprot.org/core/author"Han V.K.M."xsd:string
http://purl.uniprot.org/citations/12535528http://purl.uniprot.org/core/author"Han V.K.M."xsd:string