| http://purl.uniprot.org/citations/12538665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12538665 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12538665 | http://www.w3.org/2000/01/rdf-schema#comment | "Toll-like receptors (TLRs) and members of the proinflammatory interleukin 1 receptor (IL-1R) family are dependent on the presence of MyD88 for efficient signal transduction. The bipartite nature of MyD88 (N-terminal death domain [DD] and COOH-terminal Toll/IL-1 receptor [TIR] domain) allows it to link the TIR domain of IL-1R/TLR with the DD of the Ser/Thr kinase termed IL-1R-associated kinase (IRAK)-1. This triggers IRAK-1 phosphorylation and in turn the activation of multiple signaling cascades such as activation of the transcription factor nuclear factor (NF)-kappaB. In contrast, expression of MyD88 short (MyD88s), an alternatively spliced form of MyD88 that lacks only the short intermediate domain separating the DD and TIR domains, leads to a shutdown of IL-1/lipopolysaccharide-induced NF-kappaB activation. Here, we provide the molecular explanation for this difference. MyD88 but not MyD88s strongly interacts with IRAK-4, a newly identified kinase essential for IL-1R/TLR signaling. In the presence of MyD88s, IRAK-1 is not phosphorylated and neither activates NF-kappaB nor is ubiquitinated. Thus, MyD88s acts as a negative regulator of IL-1R/TLR/MyD88-triggered signals, leading to a transcriptionally controlled negative regulation of innate immune responses."xsd:string |
| http://purl.uniprot.org/citations/12538665 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20021790"xsd:string |
| http://purl.uniprot.org/citations/12538665 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20021790"xsd:string |
| http://purl.uniprot.org/citations/12538665 | http://purl.uniprot.org/core/author | "Burns K."xsd:string |
| http://purl.uniprot.org/citations/12538665 | http://purl.uniprot.org/core/author | "Burns K."xsd:string |
| http://purl.uniprot.org/citations/12538665 | http://purl.uniprot.org/core/author | "Tschopp J."xsd:string |
| http://purl.uniprot.org/citations/12538665 | http://purl.uniprot.org/core/author | "Tschopp J."xsd:string |
| http://purl.uniprot.org/citations/12538665 | http://purl.uniprot.org/core/author | "Beyaert R."xsd:string |
| http://purl.uniprot.org/citations/12538665 | http://purl.uniprot.org/core/author | "Beyaert R."xsd:string |
| http://purl.uniprot.org/citations/12538665 | http://purl.uniprot.org/core/author | "Janssens S."xsd:string |
| http://purl.uniprot.org/citations/12538665 | http://purl.uniprot.org/core/author | "Janssens S."xsd:string |
| http://purl.uniprot.org/citations/12538665 | http://purl.uniprot.org/core/author | "Brissoni B."xsd:string |
| http://purl.uniprot.org/citations/12538665 | http://purl.uniprot.org/core/author | "Brissoni B."xsd:string |
| http://purl.uniprot.org/citations/12538665 | http://purl.uniprot.org/core/author | "Olivos N."xsd:string |
| http://purl.uniprot.org/citations/12538665 | http://purl.uniprot.org/core/author | "Olivos N."xsd:string |
| http://purl.uniprot.org/citations/12538665 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12538665 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12538665 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/12538665 | http://purl.uniprot.org/core/name | "J. Exp. Med."xsd:string |
| http://purl.uniprot.org/citations/12538665 | http://purl.uniprot.org/core/pages | "263-268"xsd:string |
| http://purl.uniprot.org/citations/12538665 | http://purl.uniprot.org/core/pages | "263-268"xsd:string |
| http://purl.uniprot.org/citations/12538665 | http://purl.uniprot.org/core/title | "Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4."xsd:string |
| http://purl.uniprot.org/citations/12538665 | http://purl.uniprot.org/core/title | "Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4."xsd:string |