| http://purl.uniprot.org/citations/12539043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12539043 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12539043 | http://www.w3.org/2000/01/rdf-schema#comment | "Human Toll-like receptor (TLR) 3 recognizes double-stranded (ds) RNA and induces production of interferon (IFN)-beta independent of the adaptor molecules MyD88 and TIRAP. Thus, another adaptor must exist that preferentially mediates TLR3-dependent production of IFN-beta. We have identified an alternative adaptor, designated Toll-interleukin 1 receptor domain (TIR)-containing adaptor molecule (TICAM)-1, that can physically bind the TIR domain of TLR3 and activate the IFN-beta promoter in response to poly(I):poly(C). Thus, dsRNA-TLR3-dependent production of IFN-beta is mediated mainly by TICAM-1. This TICAM-1-dependent pathway may have a role in other TLR-IFN-beta pathways, which form part of the MyD88-independent cellular immune response."xsd:string |
| http://purl.uniprot.org/citations/12539043 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni886"xsd:string |
| http://purl.uniprot.org/citations/12539043 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni886"xsd:string |
| http://purl.uniprot.org/citations/12539043 | http://purl.uniprot.org/core/author | "Akazawa T."xsd:string |
| http://purl.uniprot.org/citations/12539043 | http://purl.uniprot.org/core/author | "Akazawa T."xsd:string |
| http://purl.uniprot.org/citations/12539043 | http://purl.uniprot.org/core/author | "Matsumoto M."xsd:string |
| http://purl.uniprot.org/citations/12539043 | http://purl.uniprot.org/core/author | "Matsumoto M."xsd:string |
| http://purl.uniprot.org/citations/12539043 | http://purl.uniprot.org/core/author | "Funami K."xsd:string |
| http://purl.uniprot.org/citations/12539043 | http://purl.uniprot.org/core/author | "Funami K."xsd:string |
| http://purl.uniprot.org/citations/12539043 | http://purl.uniprot.org/core/author | "Seya T."xsd:string |
| http://purl.uniprot.org/citations/12539043 | http://purl.uniprot.org/core/author | "Seya T."xsd:string |
| http://purl.uniprot.org/citations/12539043 | http://purl.uniprot.org/core/author | "Oshiumi H."xsd:string |
| http://purl.uniprot.org/citations/12539043 | http://purl.uniprot.org/core/author | "Oshiumi H."xsd:string |
| http://purl.uniprot.org/citations/12539043 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12539043 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12539043 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/12539043 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/12539043 | http://purl.uniprot.org/core/pages | "161-167"xsd:string |
| http://purl.uniprot.org/citations/12539043 | http://purl.uniprot.org/core/pages | "161-167"xsd:string |
| http://purl.uniprot.org/citations/12539043 | http://purl.uniprot.org/core/title | "TICAM-1, an adapter molecule that participates in Toll-like receptor 3 mediated interferon-beta induction."xsd:string |
| http://purl.uniprot.org/citations/12539043 | http://purl.uniprot.org/core/title | "TICAM-1, an adapter molecule that participates in Toll-like receptor 3 mediated interferon-beta induction."xsd:string |
| http://purl.uniprot.org/citations/12539043 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/12539043 | http://purl.uniprot.org/core/volume | "4"xsd:string |