| http://purl.uniprot.org/citations/12540904 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12540904 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12540904 | http://www.w3.org/2000/01/rdf-schema#comment | "The immune system must distinguish not only between self and non-self, but also between innocuous and pathological foreign antigens to prevent unnecessary or self-destructive immune responses. Unresponsiveness to harmless antigens is established through central and peripheral processes. Whereas clonal deletion and anergy are mechanisms of peripheral tolerance, active suppression by T-regulatory 1 (Tr1) cells has emerged as an essential factor in the control of autoreactive cells. Tr1 cells are CD4+ T lymphocytes that are defined by their production of interleukin 10 (IL-10) and suppression of T-helper cells; however, the physiological conditions underlying Tr1 differentiation are unknown. Here we show that co-engagement of CD3 and the complement regulator CD46 in the presence of IL-2 induces a Tr1-specific cytokine phenotype in human CD4+ T cells. These CD3/CD46-stimulated IL-10-producing CD4+ cells proliferate strongly, suppress activation of bystander T cells and acquire a memory phenotype. Our findings identify an endogenous receptor-mediated event that drives Tr1 differentiation and suggest that the complement system has a previously unappreciated role in T-cell-mediated immunity and tolerance."xsd:string |
| http://purl.uniprot.org/citations/12540904 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature01315"xsd:string |
| http://purl.uniprot.org/citations/12540904 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature01315"xsd:string |
| http://purl.uniprot.org/citations/12540904 | http://purl.uniprot.org/core/author | "Green J.M."xsd:string |
| http://purl.uniprot.org/citations/12540904 | http://purl.uniprot.org/core/author | "Green J.M."xsd:string |
| http://purl.uniprot.org/citations/12540904 | http://purl.uniprot.org/core/author | "Murphy K.M."xsd:string |
| http://purl.uniprot.org/citations/12540904 | http://purl.uniprot.org/core/author | "Murphy K.M."xsd:string |
| http://purl.uniprot.org/citations/12540904 | http://purl.uniprot.org/core/author | "Atkinson J.P."xsd:string |
| http://purl.uniprot.org/citations/12540904 | http://purl.uniprot.org/core/author | "Atkinson J.P."xsd:string |
| http://purl.uniprot.org/citations/12540904 | http://purl.uniprot.org/core/author | "Chan A.C."xsd:string |
| http://purl.uniprot.org/citations/12540904 | http://purl.uniprot.org/core/author | "Chan A.C."xsd:string |
| http://purl.uniprot.org/citations/12540904 | http://purl.uniprot.org/core/author | "Brett K.A."xsd:string |
| http://purl.uniprot.org/citations/12540904 | http://purl.uniprot.org/core/author | "Brett K.A."xsd:string |
| http://purl.uniprot.org/citations/12540904 | http://purl.uniprot.org/core/author | "Kemper C."xsd:string |
| http://purl.uniprot.org/citations/12540904 | http://purl.uniprot.org/core/author | "Kemper C."xsd:string |
| http://purl.uniprot.org/citations/12540904 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12540904 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12540904 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/12540904 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/12540904 | http://purl.uniprot.org/core/pages | "388-392"xsd:string |
| http://purl.uniprot.org/citations/12540904 | http://purl.uniprot.org/core/pages | "388-392"xsd:string |
| http://purl.uniprot.org/citations/12540904 | http://purl.uniprot.org/core/title | "Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype."xsd:string |
| http://purl.uniprot.org/citations/12540904 | http://purl.uniprot.org/core/title | "Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype."xsd:string |