| http://purl.uniprot.org/citations/12543979 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12543979 | http://www.w3.org/2000/01/rdf-schema#comment | "Disruption of the adaptor protein ELF, a beta-spectrin, leads to disruption of transforming growth factor-beta (TGF-beta) signaling by Smad proteins in mice. Elf-/- mice exhibit a phenotype similar to smad2+/-/smad3+/-mutant mice of midgestational death due to gastrointestinal, liver, neural, and heart defects. We show that TGF-beta triggers phosphorylation and association of ELF with Smad3 and Smad4, followed by nuclear translocation. ELF deficiency results in mislocalization of Smad3 and Smad4 and loss of the TGF-beta-dependent transcriptional response, which could be rescued by overexpression of the COOH-terminal region of ELF. This study reveals an unexpected molecular link between a major dynamic scaffolding protein and a key signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/12543979 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1075994"xsd:string |
| http://purl.uniprot.org/citations/12543979 | http://purl.uniprot.org/core/author | "Tang Y."xsd:string |
| http://purl.uniprot.org/citations/12543979 | http://purl.uniprot.org/core/author | "Mishra B."xsd:string |
| http://purl.uniprot.org/citations/12543979 | http://purl.uniprot.org/core/author | "Deng C.X."xsd:string |
| http://purl.uniprot.org/citations/12543979 | http://purl.uniprot.org/core/author | "Mishra L."xsd:string |
| http://purl.uniprot.org/citations/12543979 | http://purl.uniprot.org/core/author | "Dillner A."xsd:string |
| http://purl.uniprot.org/citations/12543979 | http://purl.uniprot.org/core/author | "Katuri V."xsd:string |
| http://purl.uniprot.org/citations/12543979 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12543979 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12543979 | http://purl.uniprot.org/core/pages | "574-577"xsd:string |
| http://purl.uniprot.org/citations/12543979 | http://purl.uniprot.org/core/title | "Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/12543979 | http://purl.uniprot.org/core/volume | "299"xsd:string |
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