| http://purl.uniprot.org/citations/12545156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12545156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12545156 | http://www.w3.org/2000/01/rdf-schema#comment | "Inhibition of cellular differentiation is one of the well-known biological activities of c-Myc-family proteins. We show here that Myc represses differentiation-induced expression of the cyclin-dependent kinase (CDK) inhibitor p21CIP1 (CDKN1A, p21), known to play an important role in cell fate decisions during growth and differentiation, in hematopoietic cells. Our results demonstrate that the c-Myc-responsive region is situated in the p21 core promoter. c-Myc binds to this region in vitro and in vivo through interaction with the initiator-binding Zn-finger transcription factor Miz-1, which associates directly with the promoter. Association of Myc with the promoter in vivo correlates inversely with p21 expression. Using mutants of c-Myc with impaired binding to Miz-1, our results further show that repression of p21 promoter/reporters as well as the endogenous p21 gene by Myc depends on interaction with Miz-1. Expression of Miz-1 increases during hematopoietic differentiation and Miz-1 activates the p21 promoter under conditions of low Myc levels, indicating a positive role for free Miz-1 in this process. In conclusion, repression of differentiation-induced p21 expression through Miz-1 may be an important mechanism by which Myc blocks differentiation."xsd:string |
| http://purl.uniprot.org/citations/12545156 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1206145"xsd:string |
| http://purl.uniprot.org/citations/12545156 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1206145"xsd:string |
| http://purl.uniprot.org/citations/12545156 | http://purl.uniprot.org/core/author | "Wu S."xsd:string |
| http://purl.uniprot.org/citations/12545156 | http://purl.uniprot.org/core/author | "Wu S."xsd:string |
| http://purl.uniprot.org/citations/12545156 | http://purl.uniprot.org/core/author | "Leon J."xsd:string |
| http://purl.uniprot.org/citations/12545156 | http://purl.uniprot.org/core/author | "Leon J."xsd:string |
| http://purl.uniprot.org/citations/12545156 | http://purl.uniprot.org/core/author | "Eilers M."xsd:string |
| http://purl.uniprot.org/citations/12545156 | http://purl.uniprot.org/core/author | "Eilers M."xsd:string |
| http://purl.uniprot.org/citations/12545156 | http://purl.uniprot.org/core/author | "Bahram F."xsd:string |
| http://purl.uniprot.org/citations/12545156 | http://purl.uniprot.org/core/author | "Bahram F."xsd:string |
| http://purl.uniprot.org/citations/12545156 | http://purl.uniprot.org/core/author | "Larsson L.-G."xsd:string |
| http://purl.uniprot.org/citations/12545156 | http://purl.uniprot.org/core/author | "Larsson L.-G."xsd:string |
| http://purl.uniprot.org/citations/12545156 | http://purl.uniprot.org/core/author | "von der Lehr N."xsd:string |
| http://purl.uniprot.org/citations/12545156 | http://purl.uniprot.org/core/author | "von der Lehr N."xsd:string |
| http://purl.uniprot.org/citations/12545156 | http://purl.uniprot.org/core/author | "Munoz-Alonso M.J."xsd:string |
| http://purl.uniprot.org/citations/12545156 | http://purl.uniprot.org/core/author | "Munoz-Alonso M.J."xsd:string |
| http://purl.uniprot.org/citations/12545156 | http://purl.uniprot.org/core/author | "Cetinkaya C."xsd:string |
| http://purl.uniprot.org/citations/12545156 | http://purl.uniprot.org/core/author | "Cetinkaya C."xsd:string |
| http://purl.uniprot.org/citations/12545156 | http://purl.uniprot.org/core/author | "Beuger V."xsd:string |
| http://purl.uniprot.org/citations/12545156 | http://purl.uniprot.org/core/author | "Beuger V."xsd:string |
| http://purl.uniprot.org/citations/12545156 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12545156 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |