| http://purl.uniprot.org/citations/12545159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12545159 | http://www.w3.org/2000/01/rdf-schema#comment | "Constitutive activation of the telomerase is a key step in the development of human cancers. Interferon-gamma (IFN-gamma) signaling induces growth arrest in many tumors through multiple regulatory mechanisms. In this study, we show that IFN-gamma signaling represses telomerase activity and human telomerase reverse transcriptase (hTERT) transcription, and suggest that this signaling is mediated by IRF-1. Ectopic expression of IRF-1 attenuated hTERT promoter activity. Murine embryonic fibroblasts (MEFs) genetically deficient in IRF-1 (IRF-1(-/-)) showed an elevated level (>15 times) of hTERT promoter activity as compared to the hTERT promoter activity of wild-type MEFs. The telomerase activity and hTERT expression in IRF-1(-/-) MEFs were downregulated by IRF-1 transfection. Interestingly, less extent of telomerase repression was observed in HPV E6 and E7 negative, p53 mutant HT-3 cells than in HPV 18 E6 and E7 positive HeLa cells (intact p53). These findings provide evidence that IRF-1 is a potential mediator of IFN-gamma-induced attenuation of telomerase activity and hTERT expression."xsd:string |
| http://purl.uniprot.org/citations/12545159 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1206133"xsd:string |
| http://purl.uniprot.org/citations/12545159 | http://purl.uniprot.org/core/author | "Kim Y.J."xsd:string |
| http://purl.uniprot.org/citations/12545159 | http://purl.uniprot.org/core/author | "Kim J.W."xsd:string |
| http://purl.uniprot.org/citations/12545159 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/12545159 | http://purl.uniprot.org/core/author | "Lee H.W."xsd:string |
| http://purl.uniprot.org/citations/12545159 | http://purl.uniprot.org/core/author | "Lee S.H."xsd:string |
| http://purl.uniprot.org/citations/12545159 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/12545159 | http://purl.uniprot.org/core/author | "Cho Y.S."xsd:string |
| http://purl.uniprot.org/citations/12545159 | http://purl.uniprot.org/core/author | "Oh S.H."xsd:string |
| http://purl.uniprot.org/citations/12545159 | http://purl.uniprot.org/core/author | "Jung C.H."xsd:string |
| http://purl.uniprot.org/citations/12545159 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12545159 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/12545159 | http://purl.uniprot.org/core/pages | "381-391"xsd:string |
| http://purl.uniprot.org/citations/12545159 | http://purl.uniprot.org/core/title | "Interferon regulatory factor-1 (IRF-1) is a mediator for interferon-gamma induced attenuation of telomerase activity and human telomerase reverse transcriptase (hTERT) expression."xsd:string |
| http://purl.uniprot.org/citations/12545159 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/12545159 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12545159 |
| http://purl.uniprot.org/citations/12545159 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12545159 |
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| http://purl.uniprot.org/uniprot/#_A0A510GDD8-mappedCitation-12545159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12545159 |
| http://purl.uniprot.org/uniprot/#_B4DQF0-mappedCitation-12545159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12545159 |
| http://purl.uniprot.org/uniprot/#_P10914-mappedCitation-12545159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12545159 |