| http://purl.uniprot.org/citations/12545165 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12545165 | http://www.w3.org/2000/01/rdf-schema#comment | "The human DLC-1 (deleted in liver cancer 1) gene was cloned from a primary human hepatocellular carcinoma (HCC) and mapped to the chromosome 8p21-22 region frequently deleted in common human cancers and suspected to harbor tumor suppressor genes. DLC-1 was found to be deleted or downregulated in a significant number of HCCs. We expanded our investigations to other cancers with recurrent deletions of 8p22, and in this study examined alterations of DLC-1 in primary human breast tumors, human breast, colon, and prostate tumor cell lines. Genomic deletion of DLC-1 was observed in 40% of primary breast tumors, whereas reduced or undetectable levels of DLC-1 mRNA were seen in 70% of breast, 70% of colon, and 50% of prostate tumor cell lines To see whether DLC-1 expression affects cell growth and tumorigenicity, two breast carcinoma cell lines lacking the expression of endogenous gene were transfected with the DLC-1 cDNA. In both cell lines, DLC-1 transfection caused significant growth inhibition and reduction of colony formation. Furthermore, introduction of the DLC-1 cDNA abolished the in vivo tumorigenicity in nude mice, suggesting that the DLC-1 gene plays a role in breast cancer by acting as a bona fide tumor suppressor gene."xsd:string |
| http://purl.uniprot.org/citations/12545165 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1206064"xsd:string |
| http://purl.uniprot.org/citations/12545165 | http://purl.uniprot.org/core/author | "Zhou X."xsd:string |
| http://purl.uniprot.org/citations/12545165 | http://purl.uniprot.org/core/author | "Popescu N.C."xsd:string |
| http://purl.uniprot.org/citations/12545165 | http://purl.uniprot.org/core/author | "Zimonjic D.B."xsd:string |
| http://purl.uniprot.org/citations/12545165 | http://purl.uniprot.org/core/author | "Eyfjord J.E."xsd:string |
| http://purl.uniprot.org/citations/12545165 | http://purl.uniprot.org/core/author | "Thorgeirsson S.S."xsd:string |
| http://purl.uniprot.org/citations/12545165 | http://purl.uniprot.org/core/author | "Durkin M.E."xsd:string |
| http://purl.uniprot.org/citations/12545165 | http://purl.uniprot.org/core/author | "Yuan B.Z."xsd:string |
| http://purl.uniprot.org/citations/12545165 | http://purl.uniprot.org/core/author | "Gumundsdottir K."xsd:string |
| http://purl.uniprot.org/citations/12545165 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12545165 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/12545165 | http://purl.uniprot.org/core/pages | "445-450"xsd:string |
| http://purl.uniprot.org/citations/12545165 | http://purl.uniprot.org/core/title | "DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity."xsd:string |
| http://purl.uniprot.org/citations/12545165 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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