| http://purl.uniprot.org/citations/12546819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12546819 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12546819 | http://www.w3.org/2000/01/rdf-schema#comment | "The central serotonin (5-HT) neurotransmitter system is an important modulator of diverse physiological processes and behaviors; however, the transcriptional mechanisms controlling its development are largely unknown. The Pet-1 ETS factor is a precise marker of developing and adult 5-HT neurons and is expressed shortly before 5-HT appears in the hindbrain. Here we show that in mice lacking Pet-1, the majority of 5-HT neurons fail to differentiate. Remaining ones show deficient expression of genes required for 5-HT synthesis, uptake, and storage. Significantly, defective development of the 5-HT system is followed by heightened anxiety-like and aggressive behavior in adults. These findings indicate that Pet-1 is a critical determinant of 5-HT neuron identity and implicate a Pet-1-dependent program in serotonergic modulation of behavior."xsd:string |
| http://purl.uniprot.org/citations/12546819 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(02)01167-4"xsd:string |
| http://purl.uniprot.org/citations/12546819 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(02)01167-4"xsd:string |
| http://purl.uniprot.org/citations/12546819 | http://purl.uniprot.org/core/author | "Silver J."xsd:string |
| http://purl.uniprot.org/citations/12546819 | http://purl.uniprot.org/core/author | "Silver J."xsd:string |
| http://purl.uniprot.org/citations/12546819 | http://purl.uniprot.org/core/author | "Deneris E.S."xsd:string |
| http://purl.uniprot.org/citations/12546819 | http://purl.uniprot.org/core/author | "Deneris E.S."xsd:string |
| http://purl.uniprot.org/citations/12546819 | http://purl.uniprot.org/core/author | "Yamamoto B."xsd:string |
| http://purl.uniprot.org/citations/12546819 | http://purl.uniprot.org/core/author | "Yamamoto B."xsd:string |
| http://purl.uniprot.org/citations/12546819 | http://purl.uniprot.org/core/author | "Sweatt J.D."xsd:string |
| http://purl.uniprot.org/citations/12546819 | http://purl.uniprot.org/core/author | "Sweatt J.D."xsd:string |
| http://purl.uniprot.org/citations/12546819 | http://purl.uniprot.org/core/author | "Weeber E.J."xsd:string |
| http://purl.uniprot.org/citations/12546819 | http://purl.uniprot.org/core/author | "Weeber E.J."xsd:string |
| http://purl.uniprot.org/citations/12546819 | http://purl.uniprot.org/core/author | "Fyodorov D.V."xsd:string |
| http://purl.uniprot.org/citations/12546819 | http://purl.uniprot.org/core/author | "Fyodorov D.V."xsd:string |
| http://purl.uniprot.org/citations/12546819 | http://purl.uniprot.org/core/author | "Hendricks T.J."xsd:string |
| http://purl.uniprot.org/citations/12546819 | http://purl.uniprot.org/core/author | "Hendricks T.J."xsd:string |
| http://purl.uniprot.org/citations/12546819 | http://purl.uniprot.org/core/author | "Lelutiu N.B."xsd:string |
| http://purl.uniprot.org/citations/12546819 | http://purl.uniprot.org/core/author | "Lelutiu N.B."xsd:string |
| http://purl.uniprot.org/citations/12546819 | http://purl.uniprot.org/core/author | "Pehek E.A."xsd:string |
| http://purl.uniprot.org/citations/12546819 | http://purl.uniprot.org/core/author | "Pehek E.A."xsd:string |
| http://purl.uniprot.org/citations/12546819 | http://purl.uniprot.org/core/author | "Wegman L.J."xsd:string |
| http://purl.uniprot.org/citations/12546819 | http://purl.uniprot.org/core/author | "Wegman L.J."xsd:string |