| http://purl.uniprot.org/citations/12547703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12547703 | http://www.w3.org/2000/01/rdf-schema#comment | "The terminal complement components play an important role in mediating tissue injury after ischemia and reperfusion (I/R) injury in rats and mice. However, the specific complement pathways involved in I/R injury are unknown. The role of the alternative pathway in I/R injury may be particularly important, as it amplifies complement activation and deposition. In this study, the role of the alternative pathway in I/R injury was evaluated using factor D-deficient (-/-) and heterozygote (+/-) mice. Gastrointestinal ischemia (GI) was induced by clamping the mesenteric artery for 20 minutes and then reperfused for 3 hours. Sham-operated control mice (+/-versus -/-) had similar baseline intestinal lactate dehydrogenase activity (P = ns). Intestinal lactate dehydrogenase activity was greater in -/-mice compared to +/-mice after GI/R (P = 0.02) thus demonstrating protection in the -/-mice. Intestinal myeloperoxidase activity in +/-mice was significantly greater than -/-mice after GI/R (P < 0.001). Pulmonary myeloperoxidase activity after GI/R was significantly higher in +/- than -/-mice (P = 0.03). Addition of human factor D to -/-animals restored GI/R injury and was prevented by a functionally inhibitory antibody against human factor D. These data suggest that the alternative complement pathway plays an important role in local and remote tissue injury after GI/R. Inhibition of factor D may represent an effective therapeutic approach for GI/R injury."xsd:string |
| http://purl.uniprot.org/citations/12547703 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0002-9440(10)63839-4"xsd:string |
| http://purl.uniprot.org/citations/12547703 | http://purl.uniprot.org/core/author | "Hao L."xsd:string |
| http://purl.uniprot.org/citations/12547703 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
| http://purl.uniprot.org/citations/12547703 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/12547703 | http://purl.uniprot.org/core/author | "Miller M."xsd:string |
| http://purl.uniprot.org/citations/12547703 | http://purl.uniprot.org/core/author | "Fung M."xsd:string |
| http://purl.uniprot.org/citations/12547703 | http://purl.uniprot.org/core/author | "Stahl G.L."xsd:string |
| http://purl.uniprot.org/citations/12547703 | http://purl.uniprot.org/core/author | "Buras J.A."xsd:string |
| http://purl.uniprot.org/citations/12547703 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12547703 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/12547703 | http://purl.uniprot.org/core/pages | "449-455"xsd:string |
| http://purl.uniprot.org/citations/12547703 | http://purl.uniprot.org/core/title | "Role for the alternative complement pathway in ischemia/reperfusion injury."xsd:string |
| http://purl.uniprot.org/citations/12547703 | http://purl.uniprot.org/core/volume | "162"xsd:string |
| http://purl.uniprot.org/citations/12547703 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12547703 |
| http://purl.uniprot.org/citations/12547703 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12547703 |
| http://purl.uniprot.org/uniprot/#_B7ZNS9-mappedCitation-12547703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12547703 |
| http://purl.uniprot.org/uniprot/#_Q3UP47-mappedCitation-12547703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12547703 |
| http://purl.uniprot.org/uniprot/#_P03953-mappedCitation-12547703 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12547703 |
| http://purl.uniprot.org/uniprot/P03953 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12547703 |
| http://purl.uniprot.org/uniprot/Q3UP47 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12547703 |
| http://purl.uniprot.org/uniprot/B7ZNS9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12547703 |