| http://purl.uniprot.org/citations/12551860 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12551860 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundUncoupling protein 2 (UCP2) regulates the production of reactive oxygen species in macrophages. However, its role in atherosclerosis is unknown.Methods and resultsIrradiated low-density lipoprotein receptor deficient mice (LDLR-/-) were transplanted with bone marrow from either UCP2 deficient mice (Ucp2-/-) or wild type mice (Ucp2+/+). Mice were fed an atherogenic diet for 7 weeks. Engraftment of bone marrow cells was confirmed by the presence of UCP2 protein expression in spleen cell mitochondria of Ucp2+/+ transplanted mice and its absence in Ucp2-/-transplanted mice. Leukocyte counts and plasma cholesterol levels were comparable in both groups. We found a marked increase in atherosclerotic lesion size in the thoracic aorta of Ucp2-/-transplanted mice compared with control Ucp2+/+ transplanted mice (8.3+/-0.9% versus 4.3+/-0.4%, respectively; P<0.005), as well as in the aortic sinus (150 066+/-12 388 microm2 versus 105 689+/-9 727 microm2, respectively; P<0.05). This was associated with increased nitrotyrosine staining, which suggests enhanced oxidative stress. Analysis of plaque composition revealed a significant increase in macrophage accumulation (P<0.05) and apoptosis (P<0.05), along with a decrease in collagen content (P<0.05), suggesting a potentially more vulnerable phenotype.ConclusionThese results suggest a protective role for UCP2 against atherosclerosis."xsd:string |
| http://purl.uniprot.org/citations/12551860 | http://purl.org/dc/terms/identifier | "doi:10.1161/01.cir.0000051722.66074.60"xsd:string |
| http://purl.uniprot.org/citations/12551860 | http://purl.uniprot.org/core/author | "Miroux B."xsd:string |
| http://purl.uniprot.org/citations/12551860 | http://purl.uniprot.org/core/author | "Ricquier D."xsd:string |
| http://purl.uniprot.org/citations/12551860 | http://purl.uniprot.org/core/author | "Rousset S."xsd:string |
| http://purl.uniprot.org/citations/12551860 | http://purl.uniprot.org/core/author | "Alves-Guerra M.C."xsd:string |
| http://purl.uniprot.org/citations/12551860 | http://purl.uniprot.org/core/author | "Mallat Z."xsd:string |
| http://purl.uniprot.org/citations/12551860 | http://purl.uniprot.org/core/author | "Tedgui A."xsd:string |
| http://purl.uniprot.org/citations/12551860 | http://purl.uniprot.org/core/author | "Blanc J."xsd:string |
| http://purl.uniprot.org/citations/12551860 | http://purl.uniprot.org/core/author | "Esposito B."xsd:string |
| http://purl.uniprot.org/citations/12551860 | http://purl.uniprot.org/core/author | "Gourdy P."xsd:string |
| http://purl.uniprot.org/citations/12551860 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12551860 | http://purl.uniprot.org/core/name | "Circulation"xsd:string |
| http://purl.uniprot.org/citations/12551860 | http://purl.uniprot.org/core/pages | "388-390"xsd:string |
| http://purl.uniprot.org/citations/12551860 | http://purl.uniprot.org/core/title | "Protective role of uncoupling protein 2 in atherosclerosis."xsd:string |
| http://purl.uniprot.org/citations/12551860 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/12551860 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12551860 |
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