| http://purl.uniprot.org/citations/12552087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12552087 | http://www.w3.org/2000/01/rdf-schema#comment | "The HLA-G molecule plays an important role in immune tolerance, protecting the fetus from maternal immune attack, and probably contributes to graft tolerance and tumor escape from the host immune system. HLA-G expression is tightly regulated and involves mechanisms acting in part at the transcriptional level. Nevertheless, almost all regulatory sequences that govern constitutive and inducible HLA class I gene transcription are disrupted in the HLA-G gene promoter, suggesting an unusual regulatory process. In further investigating the molecular mechanisms of HLA-G gene activation, we evaluated the influence of epigenetic mechanisms on seven HLA-G-negative cell lines that exhibit various phenotypes. Exposure of cells to histone deacetylase inhibitors, or to the demethylating agent 5-aza-2'-deoxycytidine, revealed that HLA-G gene transcription is inhibited by DNA methylation. Reversal of methylation-mediated repression may directly induce HLA-G cell-surface expression, supporting the idea that HLA-G might be activated by such a mechanism during malignancy, inflammation, and allogenic reactions."xsd:string |
| http://purl.uniprot.org/citations/12552087 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0337539100"xsd:string |
| http://purl.uniprot.org/citations/12552087 | http://purl.uniprot.org/core/author | "Moreau P."xsd:string |
| http://purl.uniprot.org/citations/12552087 | http://purl.uniprot.org/core/author | "Rousseau P."xsd:string |
| http://purl.uniprot.org/citations/12552087 | http://purl.uniprot.org/core/author | "Dausset J."xsd:string |
| http://purl.uniprot.org/citations/12552087 | http://purl.uniprot.org/core/author | "Carosella E.D."xsd:string |
| http://purl.uniprot.org/citations/12552087 | http://purl.uniprot.org/core/author | "Marcou C."xsd:string |
| http://purl.uniprot.org/citations/12552087 | http://purl.uniprot.org/core/author | "Mouillot G."xsd:string |
| http://purl.uniprot.org/citations/12552087 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12552087 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/12552087 | http://purl.uniprot.org/core/pages | "1191-1196"xsd:string |
| http://purl.uniprot.org/citations/12552087 | http://purl.uniprot.org/core/title | "HLA-G gene repression is reversed by demethylation."xsd:string |
| http://purl.uniprot.org/citations/12552087 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/12552087 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12552087 |
| http://purl.uniprot.org/citations/12552087 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12552087 |
| http://purl.uniprot.org/uniprot/#_A0A0H4M9X9-mappedCitation-12552087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12552087 |
| http://purl.uniprot.org/uniprot/#_A0A0H4M9Y0-mappedCitation-12552087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12552087 |
| http://purl.uniprot.org/uniprot/#_A0A0H4M9Y1-mappedCitation-12552087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12552087 |
| http://purl.uniprot.org/uniprot/#_A0A0H4M9Y2-mappedCitation-12552087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12552087 |
| http://purl.uniprot.org/uniprot/#_A0A0H4M9Y3-mappedCitation-12552087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12552087 |
| http://purl.uniprot.org/uniprot/#_A0A0H4M9Y6-mappedCitation-12552087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12552087 |
| http://purl.uniprot.org/uniprot/#_A0A0H4M9Z1-mappedCitation-12552087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12552087 |
| http://purl.uniprot.org/uniprot/#_A0A0H4LTX5-mappedCitation-12552087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12552087 |
| http://purl.uniprot.org/uniprot/#_A0A0H4LTX9-mappedCitation-12552087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12552087 |