Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/12553555http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12553555http://www.w3.org/2000/01/rdf-schema#comment"Data on the expression of interleukin 6 (IL-6)/interleukin 6 receptor (IL-6R) in thyroid nodules is scarce. Based on our recent data of CD30 ligand (CD30L)/CD30 receptor (CD30) in these nodules and on the knowledge that this signal stimulates IL-6 production in non-thyroid neoplasms, we wanted to evaluate the immunocytochemical expression of these 2 ligand/receptor systems in a large archival series of paraffin-embedded specimens. These specimens included 6 normal thyroids and 130 thyroid nodules. Co-expression of IL-6 and IL-6R in the epithelial (follicular) cells was observed solely in CD30L/CD30 positive nodules: 5/15 (33%) oncocytic adenomas; 6/30 (20%) follicular adenomas which belonged to 2 variants (4/4 microfollicular toxic and 2/2 hyalinizing trabecular); 9/30 (30%) papillary thyroid cancers (PTC), all belonging to the conventional variant. In PTC the proportion of tumor epithelial cells that were IL6 positive was inversely correlated with the pTNM staging (r=-0.549, p=0.01). All 15 follicular cancers (FTC), all 6 anaplastic cancers (ATC) were IL-6/lL-6R negative; 14/15 FTC and 5/6 ATC were CD30L/CD30 negative. In another oncocytic adenoma, another 4 conventional PTC and another 7 non-conventional PTC CD30L/CD30 expression was associated to expression of IL-6 only. IL-6 staining associated to absent expression of CD30L and CD30 was observed in 7 follicular adenomas (all belonging to variants different from toxic and hyalinizing trabecular), 2 oncocytic adenomas, 5 of the 30 colloid nodules and 2 normal thyroids. Of the 6 tumors arising from the parafollicular C cells (medullary thyroid cancer, MTC), all 3 that had metastasized were CD30L/CD30/IL-6 positive and IL-6R negative; only IL-6 expression was lost in both the local and distant metastases. This finding matched the loss of IL-6 expression in one PTC metastasis. All 3 non-metastasized MTC were IL-6/IL-6R negative, and 1/3 was CD30L positive/CD30 negative. We conclude that only in a subset of both benign and malignant thyroid nodules the IL-6/IL-6R signal could be induced by the CD30L/CD30. IL-6 expression is related with aggressiveness in both PTC and MTC. In the normal thyroid tissue, colloid nodules, and another subset of benign and malignant thyroid nodules, IL-6 expression is under control of signals other than CD30L/CD30."xsd:string
http://purl.uniprot.org/citations/12553555http://purl.org/dc/terms/identifier"doi:10.1007/bf03344068"xsd:string
http://purl.uniprot.org/citations/12553555http://purl.uniprot.org/core/author"Trovato M."xsd:string
http://purl.uniprot.org/citations/12553555http://purl.uniprot.org/core/author"Attard M."xsd:string
http://purl.uniprot.org/citations/12553555http://purl.uniprot.org/core/author"Villari D."xsd:string
http://purl.uniprot.org/citations/12553555http://purl.uniprot.org/core/author"Barresi G."xsd:string
http://purl.uniprot.org/citations/12553555http://purl.uniprot.org/core/author"Benvenga S."xsd:string
http://purl.uniprot.org/citations/12553555http://purl.uniprot.org/core/author"Trimarchi F."xsd:string
http://purl.uniprot.org/citations/12553555http://purl.uniprot.org/core/author"Orlandi F."xsd:string
http://purl.uniprot.org/citations/12553555http://purl.uniprot.org/core/author"Ruggeri R.M."xsd:string
http://purl.uniprot.org/citations/12553555http://purl.uniprot.org/core/author"Scarfi R."xsd:string
http://purl.uniprot.org/citations/12553555http://purl.uniprot.org/core/author"Simone A."xsd:string
http://purl.uniprot.org/citations/12553555http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/12553555http://purl.uniprot.org/core/name"J Endocrinol Invest"xsd:string
http://purl.uniprot.org/citations/12553555http://purl.uniprot.org/core/pages"959-966"xsd:string
http://purl.uniprot.org/citations/12553555http://purl.uniprot.org/core/title"Co-expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) in thyroid nodules is associated with co-expression of CD30 ligand/CD30 receptor."xsd:string
http://purl.uniprot.org/citations/12553555http://purl.uniprot.org/core/volume"25"xsd:string
http://purl.uniprot.org/citations/12553555http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12553555
http://purl.uniprot.org/citations/12553555http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12553555
http://purl.uniprot.org/uniprot/#_A0A087WTB5-mappedCitation-12553555http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12553555
http://purl.uniprot.org/uniprot/#_A0A087X228-mappedCitation-12553555http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12553555
http://purl.uniprot.org/uniprot/#_A0A1C9J7U0-mappedCitation-12553555http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12553555
http://purl.uniprot.org/uniprot/#_B4DVM1-mappedCitation-12553555http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12553555
http://purl.uniprot.org/uniprot/#_A0N0L5-mappedCitation-12553555http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12553555
▶