| http://purl.uniprot.org/citations/12553906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12553906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12553906 | http://www.w3.org/2000/01/rdf-schema#comment | "During Drosophila embryogenesis, the dorsal transcription factor activates the expression of twist, a transcription factor required for mesoderm formation. We show here that the mammalian twist proteins, twist-1 and -2, are induced by a cytokine signaling pathway that requires the dorsal-related protein RelA, a member of the NF-kappaB family of transcription factors. Twist-1 and -2 repress cytokine gene expression through interaction with RelA. Mice homozygous for a twist-2 null allele or doubly heterozygous for twist-1 and -2 alleles show elevated expression of proinflammatory cytokines, resulting in perinatal death from cachexia. These findings reveal an evolutionarily conserved signaling circuit in which twist proteins regulate cytokine signaling by establishing a negative feedback loop that represses the NF-kappaB-dependent cytokine pathway."xsd:string |
| http://purl.uniprot.org/citations/12553906 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(03)00002-3"xsd:string |
| http://purl.uniprot.org/citations/12553906 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(03)00002-3"xsd:string |
| http://purl.uniprot.org/citations/12553906 | http://purl.uniprot.org/core/author | "Yu K."xsd:string |
| http://purl.uniprot.org/citations/12553906 | http://purl.uniprot.org/core/author | "Yu K."xsd:string |
| http://purl.uniprot.org/citations/12553906 | http://purl.uniprot.org/core/author | "Olson E.N."xsd:string |
| http://purl.uniprot.org/citations/12553906 | http://purl.uniprot.org/core/author | "Olson E.N."xsd:string |
| http://purl.uniprot.org/citations/12553906 | http://purl.uniprot.org/core/author | "Richardson J.A."xsd:string |
| http://purl.uniprot.org/citations/12553906 | http://purl.uniprot.org/core/author | "Richardson J.A."xsd:string |
| http://purl.uniprot.org/citations/12553906 | http://purl.uniprot.org/core/author | "Ornitz D.M."xsd:string |
| http://purl.uniprot.org/citations/12553906 | http://purl.uniprot.org/core/author | "Ornitz D.M."xsd:string |
| http://purl.uniprot.org/citations/12553906 | http://purl.uniprot.org/core/author | "Sosic D."xsd:string |
| http://purl.uniprot.org/citations/12553906 | http://purl.uniprot.org/core/author | "Sosic D."xsd:string |
| http://purl.uniprot.org/citations/12553906 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12553906 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12553906 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/12553906 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/12553906 | http://purl.uniprot.org/core/pages | "169-180"xsd:string |
| http://purl.uniprot.org/citations/12553906 | http://purl.uniprot.org/core/pages | "169-180"xsd:string |
| http://purl.uniprot.org/citations/12553906 | http://purl.uniprot.org/core/title | "Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity."xsd:string |
| http://purl.uniprot.org/citations/12553906 | http://purl.uniprot.org/core/title | "Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity."xsd:string |
| http://purl.uniprot.org/citations/12553906 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/12553906 | http://purl.uniprot.org/core/volume | "112"xsd:string |