| http://purl.uniprot.org/citations/12556497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12556497 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12556497 | http://www.w3.org/2000/01/rdf-schema#comment | "The Wnt/beta-catenin signaling pathway regulates many developmental processes by modulating gene expression. Wnt signaling induces the stabilization of cytosolic beta-catenin, which then associates with lymphoid enhancer factor and T-cell factor (LEF-1/TCF) to form a transcription complex that activates Wnt target genes. Previously, we have shown that a specific mitogen-activated protein (MAP) kinase pathway involving the MAP kinase kinase kinase TAK1 and MAP kinase-related Nemo-like kinase (NLK) suppresses Wnt signaling. In this study, we investigated the relationships among NLK, beta-catenin, and LEF-1/TCF. We found that NLK interacts directly with LEF-1/TCF and indirectly with beta-catenin via LEF-1/TCF to form a complex. NLK phosphorylates LEF-1/TCF on two serine/threonine residues located in its central region. Mutation of both residues to alanine enhanced LEF-1 transcriptional activity and rendered it resistant to inhibition by NLK. Phosphorylation of TCF-4 by NLK inhibited DNA binding by the beta-catenin-TCF-4 complex. However, this inhibition was abrogated when a mutant form of TCF-4 was used in which both threonines were replaced with valines. These results suggest that NLK phosphorylation on these sites contributes to the down-regulation of LEF-1/TCF transcriptional activity."xsd:string |
| http://purl.uniprot.org/citations/12556497 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.23.4.1379-1389.2003"xsd:string |
| http://purl.uniprot.org/citations/12556497 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.23.4.1379-1389.2003"xsd:string |
| http://purl.uniprot.org/citations/12556497 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/12556497 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/12556497 | http://purl.uniprot.org/core/author | "Ninomiya-Tsuji J."xsd:string |
| http://purl.uniprot.org/citations/12556497 | http://purl.uniprot.org/core/author | "Ninomiya-Tsuji J."xsd:string |
| http://purl.uniprot.org/citations/12556497 | http://purl.uniprot.org/core/author | "Ishitani T."xsd:string |
| http://purl.uniprot.org/citations/12556497 | http://purl.uniprot.org/core/author | "Ishitani T."xsd:string |
| http://purl.uniprot.org/citations/12556497 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12556497 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12556497 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/12556497 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/12556497 | http://purl.uniprot.org/core/pages | "1379-1389"xsd:string |
| http://purl.uniprot.org/citations/12556497 | http://purl.uniprot.org/core/pages | "1379-1389"xsd:string |
| http://purl.uniprot.org/citations/12556497 | http://purl.uniprot.org/core/title | "Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling."xsd:string |
| http://purl.uniprot.org/citations/12556497 | http://purl.uniprot.org/core/title | "Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling."xsd:string |
| http://purl.uniprot.org/citations/12556497 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/12556497 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/12556497 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12556497 |
| http://purl.uniprot.org/citations/12556497 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12556497 |
| http://purl.uniprot.org/citations/12556497 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12556497 |
| http://purl.uniprot.org/citations/12556497 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12556497 |