| http://purl.uniprot.org/citations/12556527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12556527 | http://www.w3.org/2000/01/rdf-schema#comment | "Many cases of autosomal dominant early onset familial Alzheimer's disease result from mutations in presenilin-1 (PS1). In this study, we examined the role of the PS1 homologue gene sel-12 of Caenorhabditis elegans under oxidative stress and clarified the sel-12-induced apoptosis. A genetic null allele mutant, sel-12(ar171), showed resistance to oxidative stress and prevented mitochondrial dysfunction-induced apoptosis. On the other hand, another allele mutant, sel-12(ar131), that carries a missense mutation showed a proapoptotic activity, which may be the result of a gain of function property. Also, sel-12(ar131)-induced apoptosis was ced-3- and ced-4-dependent. Dantrolene, which specifically inhibits Ca(2+) release from endoplasmic reticulum stores, prevents sel-12(ar131)-induced apoptosis. SEL-12, which is localized in the endoplasmic reticulum, may induce apoptosis through abnormal calcium release from the endoplasmic reticulum. Together, with the previous finding that human PS1 could substitute for SEL-12, these results suggest the similar involvement of PS1-inducing apoptosis under oxidative stress and mitochondrial dysfunction in the Alzheimer's Disease brain."xsd:string |
| http://purl.uniprot.org/citations/12556527 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m212058200"xsd:string |
| http://purl.uniprot.org/citations/12556527 | http://purl.uniprot.org/core/author | "Ishii N."xsd:string |
| http://purl.uniprot.org/citations/12556527 | http://purl.uniprot.org/core/author | "Shimohama S."xsd:string |
| http://purl.uniprot.org/citations/12556527 | http://purl.uniprot.org/core/author | "Kitagawa N."xsd:string |
| http://purl.uniprot.org/citations/12556527 | http://purl.uniprot.org/core/author | "Uemura K."xsd:string |
| http://purl.uniprot.org/citations/12556527 | http://purl.uniprot.org/core/author | "Kohno R."xsd:string |
| http://purl.uniprot.org/citations/12556527 | http://purl.uniprot.org/core/author | "Kuzuya A."xsd:string |
| http://purl.uniprot.org/citations/12556527 | http://purl.uniprot.org/core/author | "Shibasaki H."xsd:string |
| http://purl.uniprot.org/citations/12556527 | http://purl.uniprot.org/core/author | "Oeda T."xsd:string |
| http://purl.uniprot.org/citations/12556527 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12556527 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12556527 | http://purl.uniprot.org/core/pages | "12130-12134"xsd:string |
| http://purl.uniprot.org/citations/12556527 | http://purl.uniprot.org/core/title | "The role of the presenilin-1 homologue gene sel-12 of Caenorhabditis elegans in apoptotic activities."xsd:string |
| http://purl.uniprot.org/citations/12556527 | http://purl.uniprot.org/core/volume | "278"xsd:string |
| http://purl.uniprot.org/citations/12556527 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12556527 |
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| http://purl.uniprot.org/uniprot/#_P41956-mappedCitation-12556527 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12556527 |
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