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| http://purl.uniprot.org/citations/12558660 | http://www.w3.org/2000/01/rdf-schema#comment | "RAIDD (RIP-associated ICH-1 homologous protein with a death domain) is an adaptor molecule that mediates the action of cysteine proteases involved in apoptosis. To study the possibility of a novel system of cell ablation mediated by RAIDD, a preadipocyte cell line (3T3L1) was stably transfected with a plasmid containing the murine Raidd cDNA under the control of the adipocyte specific promoter aP2. Instead of the expected apoptosis, a blockage to differentiation upon hormonal induction was observed as judged by an absence of lipid accumulation, a lack of expression of adipocyte-specific genes and a fibroblastic appearance. Proliferation rate of Raidd-transfected clones remained unaffected. Overexpression of Raidd cDNA in 3T3L1 cell therefore inhibited differentiation, suggesting that Raidd plays a role in controlling differentiation of mouse preadipocytes and, perhaps, in other cell types, in addition to its established role in apoptosis."xsd:string |
| http://purl.uniprot.org/citations/12558660 | http://purl.org/dc/terms/identifier | "doi:10.1046/j.1365-2184.2003.00253.x"xsd:string |
| http://purl.uniprot.org/citations/12558660 | http://purl.uniprot.org/core/author | "Clark A.J."xsd:string |
| http://purl.uniprot.org/citations/12558660 | http://purl.uniprot.org/core/author | "Clinton M."xsd:string |
| http://purl.uniprot.org/citations/12558660 | http://purl.uniprot.org/core/author | "Horvat S."xsd:string |
| http://purl.uniprot.org/citations/12558660 | http://purl.uniprot.org/core/author | "Felmer R."xsd:string |
| http://purl.uniprot.org/citations/12558660 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12558660 | http://purl.uniprot.org/core/name | "Cell Prolif"xsd:string |
| http://purl.uniprot.org/citations/12558660 | http://purl.uniprot.org/core/pages | "45-54"xsd:string |
| http://purl.uniprot.org/citations/12558660 | http://purl.uniprot.org/core/title | "Overexpression of Raidd cDNA inhibits differentiation of mouse preadipocytes."xsd:string |
| http://purl.uniprot.org/citations/12558660 | http://purl.uniprot.org/core/volume | "36"xsd:string |
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