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http://purl.uniprot.org/citations/12559390http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12559390http://www.w3.org/2000/01/rdf-schema#comment"BMP-3b is a novel BMP-3-related protein and its biological functions are unknown. In order to investigate the biological actions of BMP-3b, we constructed a BMP-3b-expressing recombinant adenoviral vector (AxCAKBMP-3b). We show that over expression of BMP-3b stimulated the induction of differentiation and the osteoinduction activity of a human BMP-2-expressing recombinant adenoviral vector (AxCAOBMP-2). C2C12 cells were infected in vitro with AxCAKBMP-3b, AxCAOBMP-2 and a control vector containing no foreign genes (AxCAwt). Cells infected with AxCAOBMP-2 and AxCAKBMP-3b produced more alkaline phosphatase and secreted more osteocalcin into the culture medium than cells infected with AxCAOBMP-2 and AxCAwt. When AxCAOBMP-2, AxCAKBMP-3b, and AxCAwt were injected into the calf muscles of nude rats (F 344/N Jcl-rnu), the osteoinduction seen with AxCAOBMP-2 and AxCAKBMP-3b was greater than that seen with AxCAOBMP-2 and AxCAwt."xsd:string
http://purl.uniprot.org/citations/12559390http://purl.org/dc/terms/identifier"doi:10.1016/s0024-3205(02)02477-3"xsd:string
http://purl.uniprot.org/citations/12559390http://purl.uniprot.org/core/author"Iizuka T."xsd:string
http://purl.uniprot.org/citations/12559390http://purl.uniprot.org/core/author"Nakao K."xsd:string
http://purl.uniprot.org/citations/12559390http://purl.uniprot.org/core/author"Miura M."xsd:string
http://purl.uniprot.org/citations/12559390http://purl.uniprot.org/core/author"Okubo Y."xsd:string
http://purl.uniprot.org/citations/12559390http://purl.uniprot.org/core/author"Komatsu Y."xsd:string
http://purl.uniprot.org/citations/12559390http://purl.uniprot.org/core/author"Miyatake S."xsd:string
http://purl.uniprot.org/citations/12559390http://purl.uniprot.org/core/author"Bessho K."xsd:string
http://purl.uniprot.org/citations/12559390http://purl.uniprot.org/core/author"Kaihara S."xsd:string
http://purl.uniprot.org/citations/12559390http://purl.uniprot.org/core/author"Sonobe J."xsd:string
http://purl.uniprot.org/citations/12559390http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12559390http://purl.uniprot.org/core/name"Life Sci"xsd:string
http://purl.uniprot.org/citations/12559390http://purl.uniprot.org/core/pages"1683-1693"xsd:string
http://purl.uniprot.org/citations/12559390http://purl.uniprot.org/core/title"Over expression of bone morphogenetic protein-3b (BMP-3b) using an adenoviral vector promote the osteoblastic differentiation in C2C12 cells and augment the bone formation induced by bone morphogenetic protein-2 (BMP-2) in rats."xsd:string
http://purl.uniprot.org/citations/12559390http://purl.uniprot.org/core/volume"72"xsd:string
http://purl.uniprot.org/citations/12559390http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12559390
http://purl.uniprot.org/citations/12559390http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12559390
http://purl.uniprot.org/uniprot/P55108#attribution-DEBB3F99C4A854942DCE1D1B8A76FCBFhttp://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/12559390
http://purl.uniprot.org/uniprot/#_A0A0G2JVQ8-mappedCitation-12559390http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12559390
http://purl.uniprot.org/uniprot/#_P55108-mappedCitation-12559390http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12559390
http://purl.uniprot.org/uniprot/P55108http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/12559390
http://purl.uniprot.org/uniprot/A0A0G2JVQ8http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/12559390