| http://purl.uniprot.org/citations/12560074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12560074 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12560074 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatitis C virus (HCV) cannot be grown in vitro, making biochemical identification of new drug targets especially important. HCV p7 is a small hydrophobic protein of unknown function, yet necessary for particle infectivity in related viruses [Harada, T. et al., (2000) J. Virol. 74, 9498-9506]. We show that p7 can be cross-linked in vivo as hexamers. Escherichia coli expressed p7 fusion proteins also form hexamers in vitro. These and HIS-tagged p7 function as calcium ion channels in black lipid membranes. This activity is abrogated by Amantadine, a compound that inhibits ion channels of influenza [Hay, A.J. et al. (1985) EMBO J. 4, 3021-3024; Duff, K.C. and Ashley, R.H. (1992) Virology 190, 485-489] and has recently been shown to be active in combination with current HCV therapies."xsd:string |
| http://purl.uniprot.org/citations/12560074 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(02)03851-6"xsd:string |
| http://purl.uniprot.org/citations/12560074 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(02)03851-6"xsd:string |
| http://purl.uniprot.org/citations/12560074 | http://purl.uniprot.org/core/author | "Jaeger J."xsd:string |
| http://purl.uniprot.org/citations/12560074 | http://purl.uniprot.org/core/author | "Jaeger J."xsd:string |
| http://purl.uniprot.org/citations/12560074 | http://purl.uniprot.org/core/author | "Evans S.D."xsd:string |
| http://purl.uniprot.org/citations/12560074 | http://purl.uniprot.org/core/author | "Evans S.D."xsd:string |
| http://purl.uniprot.org/citations/12560074 | http://purl.uniprot.org/core/author | "Rowlands D.J."xsd:string |
| http://purl.uniprot.org/citations/12560074 | http://purl.uniprot.org/core/author | "Rowlands D.J."xsd:string |
| http://purl.uniprot.org/citations/12560074 | http://purl.uniprot.org/core/author | "Beales L.P."xsd:string |
| http://purl.uniprot.org/citations/12560074 | http://purl.uniprot.org/core/author | "Beales L.P."xsd:string |
| http://purl.uniprot.org/citations/12560074 | http://purl.uniprot.org/core/author | "Clarke D.S."xsd:string |
| http://purl.uniprot.org/citations/12560074 | http://purl.uniprot.org/core/author | "Clarke D.S."xsd:string |
| http://purl.uniprot.org/citations/12560074 | http://purl.uniprot.org/core/author | "Griffin S.D."xsd:string |
| http://purl.uniprot.org/citations/12560074 | http://purl.uniprot.org/core/author | "Griffin S.D."xsd:string |
| http://purl.uniprot.org/citations/12560074 | http://purl.uniprot.org/core/author | "Harris M.P."xsd:string |
| http://purl.uniprot.org/citations/12560074 | http://purl.uniprot.org/core/author | "Harris M.P."xsd:string |
| http://purl.uniprot.org/citations/12560074 | http://purl.uniprot.org/core/author | "Worsfold O."xsd:string |
| http://purl.uniprot.org/citations/12560074 | http://purl.uniprot.org/core/author | "Worsfold O."xsd:string |
| http://purl.uniprot.org/citations/12560074 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12560074 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12560074 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/12560074 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |