| http://purl.uniprot.org/citations/12560552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12560552 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12560552 | http://www.w3.org/2000/01/rdf-schema#comment | "mahoganoid is a mouse coat-color mutation whose pigmentary phenotype and genetic interactions resemble those of Attractin (Atrn). Atrn mutations also cause spongiform neurodegeneration. Here, we show that a null mutation for mahoganoid causes a similar age-dependent neuropathology that includes many features of prion diseases but without accumulation of protease-resistant prion protein. The gene mutated in mahoganoid encodes a RING-containing protein with E3 ubiquitin ligase activity in vitro. Similarities in phenotype, expression, and genetic interactions suggest that mahoganoid and Atrn genes are part of a conserved pathway for regulated protein turnover whose function is essential for neuronal viability."xsd:string |
| http://purl.uniprot.org/citations/12560552 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1079694"xsd:string |
| http://purl.uniprot.org/citations/12560552 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1079694"xsd:string |
| http://purl.uniprot.org/citations/12560552 | http://purl.uniprot.org/core/author | "He L."xsd:string |
| http://purl.uniprot.org/citations/12560552 | http://purl.uniprot.org/core/author | "He L."xsd:string |
| http://purl.uniprot.org/citations/12560552 | http://purl.uniprot.org/core/author | "Watson S.J."xsd:string |
| http://purl.uniprot.org/citations/12560552 | http://purl.uniprot.org/core/author | "Watson S.J."xsd:string |
| http://purl.uniprot.org/citations/12560552 | http://purl.uniprot.org/core/author | "Jackson P.K."xsd:string |
| http://purl.uniprot.org/citations/12560552 | http://purl.uniprot.org/core/author | "Jackson P.K."xsd:string |
| http://purl.uniprot.org/citations/12560552 | http://purl.uniprot.org/core/author | "Barsh G.S."xsd:string |
| http://purl.uniprot.org/citations/12560552 | http://purl.uniprot.org/core/author | "Barsh G.S."xsd:string |
| http://purl.uniprot.org/citations/12560552 | http://purl.uniprot.org/core/author | "Gunn T.M."xsd:string |
| http://purl.uniprot.org/citations/12560552 | http://purl.uniprot.org/core/author | "Gunn T.M."xsd:string |
| http://purl.uniprot.org/citations/12560552 | http://purl.uniprot.org/core/author | "Eldridge A.G."xsd:string |
| http://purl.uniprot.org/citations/12560552 | http://purl.uniprot.org/core/author | "Eldridge A.G."xsd:string |
| http://purl.uniprot.org/citations/12560552 | http://purl.uniprot.org/core/author | "Jolly A.F."xsd:string |
| http://purl.uniprot.org/citations/12560552 | http://purl.uniprot.org/core/author | "Jolly A.F."xsd:string |
| http://purl.uniprot.org/citations/12560552 | http://purl.uniprot.org/core/author | "Lu X.-Y."xsd:string |
| http://purl.uniprot.org/citations/12560552 | http://purl.uniprot.org/core/author | "Lu X.-Y."xsd:string |
| http://purl.uniprot.org/citations/12560552 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12560552 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12560552 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12560552 | http://purl.uniprot.org/core/name | "Science"xsd:string |