| http://purl.uniprot.org/citations/12565742 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12565742 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12565742 | http://www.w3.org/2000/01/rdf-schema#comment | "Three peptide toxins (gigantoxins I-III) with crab toxicity were isolated from the sea anemone Stichodactyla gigantea by gel filtration on Sephadex G-50 and reverse-phase HPLC on TSKgel ODS-120T and their complete amino acid sequences were determined. Gigantoxins II (44 residues) and III (48 residues) have LD(50) (against crabs) of 70 and 120 microg/kg, respectively, and are analogous to the known type 1 and 2 sea anemone sodium channel toxins, respectively. On the other hand, gigantoxin I (48 residues) is potently paralytic to crabs (ED(50) 215 microg/kg), although its lethality is very weak (LD(50)>1000 microg/kg). Interestingly, gigantoxin I has 31-33% homologies with mammalian epidermal growth factors (EGFs), with the same location of six cysteine residues. In accordance with the sequence similarity, gigantoxin I exhibits EGF activity as evidenced by rounding of A431 cells and tyrosine phosphorylation of the EGF receptor in the cells, although much less potently than human EGF. Gigantoxin I is the first example of EGF-like toxins of natural origin."xsd:string |
| http://purl.uniprot.org/citations/12565742 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0041-0101(02)00281-7"xsd:string |
| http://purl.uniprot.org/citations/12565742 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0041-0101(02)00281-7"xsd:string |
| http://purl.uniprot.org/citations/12565742 | http://purl.uniprot.org/core/author | "Ishida M."xsd:string |
| http://purl.uniprot.org/citations/12565742 | http://purl.uniprot.org/core/author | "Ishida M."xsd:string |
| http://purl.uniprot.org/citations/12565742 | http://purl.uniprot.org/core/author | "Nagashima Y."xsd:string |
| http://purl.uniprot.org/citations/12565742 | http://purl.uniprot.org/core/author | "Nagashima Y."xsd:string |
| http://purl.uniprot.org/citations/12565742 | http://purl.uniprot.org/core/author | "Shiomi K."xsd:string |
| http://purl.uniprot.org/citations/12565742 | http://purl.uniprot.org/core/author | "Shiomi K."xsd:string |
| http://purl.uniprot.org/citations/12565742 | http://purl.uniprot.org/core/author | "Honma T."xsd:string |
| http://purl.uniprot.org/citations/12565742 | http://purl.uniprot.org/core/author | "Honma T."xsd:string |
| http://purl.uniprot.org/citations/12565742 | http://purl.uniprot.org/core/author | "Chino M."xsd:string |
| http://purl.uniprot.org/citations/12565742 | http://purl.uniprot.org/core/author | "Chino M."xsd:string |
| http://purl.uniprot.org/citations/12565742 | http://purl.uniprot.org/core/author | "Ide M."xsd:string |
| http://purl.uniprot.org/citations/12565742 | http://purl.uniprot.org/core/author | "Ide M."xsd:string |
| http://purl.uniprot.org/citations/12565742 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12565742 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12565742 | http://purl.uniprot.org/core/name | "Toxicon"xsd:string |
| http://purl.uniprot.org/citations/12565742 | http://purl.uniprot.org/core/name | "Toxicon"xsd:string |
| http://purl.uniprot.org/citations/12565742 | http://purl.uniprot.org/core/pages | "229-236"xsd:string |
| http://purl.uniprot.org/citations/12565742 | http://purl.uniprot.org/core/pages | "229-236"xsd:string |
| http://purl.uniprot.org/citations/12565742 | http://purl.uniprot.org/core/title | "An epidermal growth factor-like toxin and two sodium channel toxins from the sea anemone Stichodactyla gigantea."xsd:string |
| http://purl.uniprot.org/citations/12565742 | http://purl.uniprot.org/core/title | "An epidermal growth factor-like toxin and two sodium channel toxins from the sea anemone Stichodactyla gigantea."xsd:string |