| http://purl.uniprot.org/citations/12565823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12565823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12565823 | http://www.w3.org/2000/01/rdf-schema#comment | "The CLK/STY kinases are a family of dual-specificity protein kinases implicated in the regulation of cellular growth and differentiation. Some of the kinases in the family are shown to phosphorylate serine-arginine-rich splicing factors and to regulate pre-mRNA splicing. However, the actual cellular mechanism that regulates cell growth, differentiation, and development by CLK/STY remains unclear. Here we show that a functionally conserved CLK/STY kinase exists in Schizosaccharomyces pombe, and this orthologue, called Kic1, regulates the cell surface and septum formation as well as a late step in cytokinesis. The Kic1 protein is modified in vivo, likely by phosphorylation, suggesting that it can be involved in a control cascade. In addition, kic1(+) together with dsk1(+), which encodes a related SR-specific protein kinase, constitutes a critical in vivo function for cell growth. The results provide the first in vivo evidence for the functional conservation of the CLK/STY family through evolution from fission yeast to mammals. Furthermore, since cell division and cell-cell interaction are fundamental for the differentiation and development of an organism, the novel cellular role of kic1(+) revealed from this study offers a clue to the understanding of its counterparts in higher eukaryotes."xsd:string |
| http://purl.uniprot.org/citations/12565823 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-4827(02)00022-8"xsd:string |
| http://purl.uniprot.org/citations/12565823 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-4827(02)00022-8"xsd:string |
| http://purl.uniprot.org/citations/12565823 | http://purl.uniprot.org/core/author | "Chen T."xsd:string |
| http://purl.uniprot.org/citations/12565823 | http://purl.uniprot.org/core/author | "Chen T."xsd:string |
| http://purl.uniprot.org/citations/12565823 | http://purl.uniprot.org/core/author | "Tang Z."xsd:string |
| http://purl.uniprot.org/citations/12565823 | http://purl.uniprot.org/core/author | "Tang Z."xsd:string |
| http://purl.uniprot.org/citations/12565823 | http://purl.uniprot.org/core/author | "Yanagida M."xsd:string |
| http://purl.uniprot.org/citations/12565823 | http://purl.uniprot.org/core/author | "Yanagida M."xsd:string |
| http://purl.uniprot.org/citations/12565823 | http://purl.uniprot.org/core/author | "Lin R.-J."xsd:string |
| http://purl.uniprot.org/citations/12565823 | http://purl.uniprot.org/core/author | "Lin R.-J."xsd:string |
| http://purl.uniprot.org/citations/12565823 | http://purl.uniprot.org/core/author | "Lin C.X."xsd:string |
| http://purl.uniprot.org/citations/12565823 | http://purl.uniprot.org/core/author | "Lin C.X."xsd:string |
| http://purl.uniprot.org/citations/12565823 | http://purl.uniprot.org/core/author | "Mandel L.L."xsd:string |
| http://purl.uniprot.org/citations/12565823 | http://purl.uniprot.org/core/author | "Mandel L.L."xsd:string |
| http://purl.uniprot.org/citations/12565823 | http://purl.uniprot.org/core/author | "Yean S.-L."xsd:string |
| http://purl.uniprot.org/citations/12565823 | http://purl.uniprot.org/core/author | "Yean S.-L."xsd:string |
| http://purl.uniprot.org/citations/12565823 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12565823 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12565823 | http://purl.uniprot.org/core/name | "Exp. Cell Res."xsd:string |
| http://purl.uniprot.org/citations/12565823 | http://purl.uniprot.org/core/name | "Exp. Cell Res."xsd:string |
| http://purl.uniprot.org/citations/12565823 | http://purl.uniprot.org/core/pages | "101-115"xsd:string |
| http://purl.uniprot.org/citations/12565823 | http://purl.uniprot.org/core/pages | "101-115"xsd:string |