| http://purl.uniprot.org/citations/12566314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12566314 | http://www.w3.org/2000/01/rdf-schema#comment | "We have isolated Ubp41, a ubiquitin-specific protease, in a screen for proapoptoticgenes. We found that overexpression of Ubp41 is sufficient to elicit all features of apoptosis in human cells. In contrast, an enzymatically defective UBP41 mutant and homologous ubiquitin-processing protease family members did not significantly induce cell death. Overexpression of Ubp41 resulted in a strong deubiquitination of a broad range of proteins, but surprisingly did not lead to a stabilization of protein substrates known to be regulated by the ubiquitin-proteasome system such as the cell cycle factors p21 and p27. Hence, in contrast to the proteasome inhibitor MG132, Ubp41 overexpression did not arrest cells in G(2)/M. Rather, overexpression of hUbp41 seems to interfere with the ubiquitin-system and to cause the activation of apoptosis pathways by stabilizing specific substrates. Hence, for the first time we found that a member of the deubiquitinating enzymes has a direct proapoptotic activity additionally tightening the connection between apoptosis and the ubiquitin-proteasome system."xsd:string |
| http://purl.uniprot.org/citations/12566314 | http://purl.uniprot.org/core/author | "Grimm S."xsd:string |
| http://purl.uniprot.org/citations/12566314 | http://purl.uniprot.org/core/author | "Gewies A."xsd:string |
| http://purl.uniprot.org/citations/12566314 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12566314 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/12566314 | http://purl.uniprot.org/core/pages | "682-688"xsd:string |
| http://purl.uniprot.org/citations/12566314 | http://purl.uniprot.org/core/title | "UBP41 is a proapoptotic ubiquitin-specific protease."xsd:string |
| http://purl.uniprot.org/citations/12566314 | http://purl.uniprot.org/core/volume | "63"xsd:string |
| http://purl.uniprot.org/citations/12566314 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12566314 |
| http://purl.uniprot.org/citations/12566314 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12566314 |
| http://purl.uniprot.org/uniprot/#_B7Z7C2-mappedCitation-12566314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12566314 |
| http://purl.uniprot.org/uniprot/#_O75604-mappedCitation-12566314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12566314 |
| http://purl.uniprot.org/uniprot/O75604 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12566314 |
| http://purl.uniprot.org/uniprot/B7Z7C2 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12566314 |