| http://purl.uniprot.org/citations/12566447 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12566447 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12566447 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumor necrosis factor receptor-associated factor 6 (TRAF6) transduces signals from members of the Toll/interleukin-1 (IL-1) receptor family by interacting with IL-1 receptor-associated kinase-1 (IRAK-1) after IRAK-1 is released from the receptor-MyD88 complex upon IL-1 stimulation. However, the molecular mechanisms underlying regulation of the IRAK-1/TRAF6 interaction are largely unknown. We have identified TIFA, a TRAF-interacting protein with a forkhead-associated (FHA) domain. The FHA domain is a motif known to bind directly to phosphothreonine and phosphoserine. In transient transfection assays, TIFA activates NFkappaBeta and c-Jun amino-terminal kinase. However, TIFA carrying a mutation that abolishes TRAF6 binding or mutations in the FHA domain that are known to abolish FHA domain binding to phosphopeptide fails to activate NFkappaBeta and c-Jun amino-terminal kinase. TIFA, when overexpressed, binds both TRAF6 and IRAK-1 and significantly enhances the IRAK-1/TRAF6 interaction. Furthermore, analysis of endogenous proteins indicates that TIFA associates with TRAF6 constitutively, whereas it associates with IRAK-1 in an IL-1 stimulation-dependent manner in vivo. Thus, TIFA is likely to mediate IRAK-1/TRAF6 interaction upon IL-1 stimulation."xsd:string |
| http://purl.uniprot.org/citations/12566447 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m300720200"xsd:string |
| http://purl.uniprot.org/citations/12566447 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m300720200"xsd:string |
| http://purl.uniprot.org/citations/12566447 | http://purl.uniprot.org/core/author | "Inoue J."xsd:string |
| http://purl.uniprot.org/citations/12566447 | http://purl.uniprot.org/core/author | "Inoue J."xsd:string |
| http://purl.uniprot.org/citations/12566447 | http://purl.uniprot.org/core/author | "Kato H."xsd:string |
| http://purl.uniprot.org/citations/12566447 | http://purl.uniprot.org/core/author | "Kato H."xsd:string |
| http://purl.uniprot.org/citations/12566447 | http://purl.uniprot.org/core/author | "Umezawa K."xsd:string |
| http://purl.uniprot.org/citations/12566447 | http://purl.uniprot.org/core/author | "Umezawa K."xsd:string |
| http://purl.uniprot.org/citations/12566447 | http://purl.uniprot.org/core/author | "Yamagata Y."xsd:string |
| http://purl.uniprot.org/citations/12566447 | http://purl.uniprot.org/core/author | "Yamagata Y."xsd:string |
| http://purl.uniprot.org/citations/12566447 | http://purl.uniprot.org/core/author | "Okamoto Y."xsd:string |
| http://purl.uniprot.org/citations/12566447 | http://purl.uniprot.org/core/author | "Okamoto Y."xsd:string |
| http://purl.uniprot.org/citations/12566447 | http://purl.uniprot.org/core/author | "Akiyama T."xsd:string |
| http://purl.uniprot.org/citations/12566447 | http://purl.uniprot.org/core/author | "Akiyama T."xsd:string |
| http://purl.uniprot.org/citations/12566447 | http://purl.uniprot.org/core/author | "Moriya A."xsd:string |
| http://purl.uniprot.org/citations/12566447 | http://purl.uniprot.org/core/author | "Moriya A."xsd:string |
| http://purl.uniprot.org/citations/12566447 | http://purl.uniprot.org/core/author | "Otsuka M."xsd:string |
| http://purl.uniprot.org/citations/12566447 | http://purl.uniprot.org/core/author | "Otsuka M."xsd:string |
| http://purl.uniprot.org/citations/12566447 | http://purl.uniprot.org/core/author | "Semba K."xsd:string |
| http://purl.uniprot.org/citations/12566447 | http://purl.uniprot.org/core/author | "Semba K."xsd:string |
| http://purl.uniprot.org/citations/12566447 | http://purl.uniprot.org/core/author | "Gohda J."xsd:string |
| http://purl.uniprot.org/citations/12566447 | http://purl.uniprot.org/core/author | "Gohda J."xsd:string |