| http://purl.uniprot.org/citations/12569093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12569093 | http://www.w3.org/2000/01/rdf-schema#comment | "The Abl family of mammalian nonreceptor tyrosine kinases consists of c-Abl and Arg. Recent work has shown that c-Abl and Arg are activated in the cellular response to oxidative stress. The present studies demonstrate that reactive oxygen species (ROS) induce the formation of c-Abl and Arg heterodimers. The results show that the c-Abl SH3 domain binds directly to a proline-rich site (amino acids 567-576) in the Arg C-terminal region. Formation of c-Abl.Arg heterodimers also involves direct binding of the Arg Src homology 3 domain to the C-terminal region of c-Abl. The results further demonstrate that the interaction between c-Abl and Arg involves c-Abl-mediated phosphorylation of Arg. The functional significance of the c-Abl-Arg interaction is supported by the demonstration that both c-Abl and Arg are required for ROS-induced apoptosis. These findings indicate that ROS induce c-Abl.Arg heterodimers and that both c-Abl and Arg are necessary as effectors in the apoptotic response to oxidative stress."xsd:string |
| http://purl.uniprot.org/citations/12569093 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m300058200"xsd:string |
| http://purl.uniprot.org/citations/12569093 | http://purl.uniprot.org/core/author | "Cao C."xsd:string |
| http://purl.uniprot.org/citations/12569093 | http://purl.uniprot.org/core/author | "Li C."xsd:string |
| http://purl.uniprot.org/citations/12569093 | http://purl.uniprot.org/core/author | "Kufe D."xsd:string |
| http://purl.uniprot.org/citations/12569093 | http://purl.uniprot.org/core/author | "Leng Y."xsd:string |
| http://purl.uniprot.org/citations/12569093 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12569093 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12569093 | http://purl.uniprot.org/core/pages | "12961-12967"xsd:string |
| http://purl.uniprot.org/citations/12569093 | http://purl.uniprot.org/core/title | "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response."xsd:string |
| http://purl.uniprot.org/citations/12569093 | http://purl.uniprot.org/core/volume | "278"xsd:string |
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