| http://purl.uniprot.org/citations/12570369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12570369 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent efforts in the field of thrombin inhibitor research have focused on the identification of compounds with good oral bioavailability and pharmacokinetics. In this manuscript we describe a metabolism-based approach to the optimization of the 3-(2-phenethylamino)-6-methylpyrazinone acetamide template (e.g., 1) which resulted in the modification of each of the three principal components (i.e., P1, P2, P3) comprising this series. As a result of these studies, several potent thrombin inhibitors (e.g., 20, 24, 25) were identified which exhibit high levels of oral bioavailability and long plasma half-lives."xsd:string |
| http://purl.uniprot.org/citations/12570369 | http://purl.org/dc/terms/identifier | "doi:10.1021/jm020311f"xsd:string |
| http://purl.uniprot.org/citations/12570369 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/12570369 | http://purl.uniprot.org/core/author | "Yan Y."xsd:string |
| http://purl.uniprot.org/citations/12570369 | http://purl.uniprot.org/core/author | "Wong B."xsd:string |
| http://purl.uniprot.org/citations/12570369 | http://purl.uniprot.org/core/author | "Singh R."xsd:string |
| http://purl.uniprot.org/citations/12570369 | http://purl.uniprot.org/core/author | "Robinson K.A."xsd:string |
| http://purl.uniprot.org/citations/12570369 | http://purl.uniprot.org/core/author | "Kuo L."xsd:string |
| http://purl.uniprot.org/citations/12570369 | http://purl.uniprot.org/core/author | "Gardell S.J."xsd:string |
| http://purl.uniprot.org/citations/12570369 | http://purl.uniprot.org/core/author | "Lyle T.A."xsd:string |
| http://purl.uniprot.org/citations/12570369 | http://purl.uniprot.org/core/author | "Shafer J.A."xsd:string |
| http://purl.uniprot.org/citations/12570369 | http://purl.uniprot.org/core/author | "Williams P.D."xsd:string |
| http://purl.uniprot.org/citations/12570369 | http://purl.uniprot.org/core/author | "Lewis S.D."xsd:string |
| http://purl.uniprot.org/citations/12570369 | http://purl.uniprot.org/core/author | "Lynch J.J. Jr."xsd:string |
| http://purl.uniprot.org/citations/12570369 | http://purl.uniprot.org/core/author | "White R.B."xsd:string |
| http://purl.uniprot.org/citations/12570369 | http://purl.uniprot.org/core/author | "Lucas B.J."xsd:string |
| http://purl.uniprot.org/citations/12570369 | http://purl.uniprot.org/core/author | "Krueger J.A."xsd:string |
| http://purl.uniprot.org/citations/12570369 | http://purl.uniprot.org/core/author | "Lyle E.A."xsd:string |
| http://purl.uniprot.org/citations/12570369 | http://purl.uniprot.org/core/author | "McMasters D.R."xsd:string |
| http://purl.uniprot.org/citations/12570369 | http://purl.uniprot.org/core/author | "Cook J.J."xsd:string |
| http://purl.uniprot.org/citations/12570369 | http://purl.uniprot.org/core/author | "Vacca J.P."xsd:string |
| http://purl.uniprot.org/citations/12570369 | http://purl.uniprot.org/core/author | "Dorsey B.D."xsd:string |
| http://purl.uniprot.org/citations/12570369 | http://purl.uniprot.org/core/author | "Coburn C.A."xsd:string |
| http://purl.uniprot.org/citations/12570369 | http://purl.uniprot.org/core/author | "Holahan M.A."xsd:string |