| http://purl.uniprot.org/citations/12574101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12574101 | http://www.w3.org/2000/01/rdf-schema#comment | "Recently, the concept of local renin-angiotensin systems (RAS) capable of generating angiotensin II apart from the circulation has received considerable attention. To investigate this, we generated ACE 1/3 mice in which one allele of ACE is null and the second allele was engineered to express ACE on the surface of hepatocytes. ACE 1/3 mice express no endothelial ACE and lack ACE within the lungs. Their kidneys contain <7.8% the enzyme levels present in control mice. Plasma conversion of angiotensin I to angiotensin II was 43.3% normal. The baseline blood pressure and renal function of the ACE 1/3 mice were normal, probably as a function of a marked increase of both plasma angiotensin I and angiotensin II. When exposed to 2 weeks of a salt-free diet (a stress diet stimulating the RAS), blood pressure in ACE 1/3 mice decreased to 92.3+/-2.0 mm Hg, a level significantly lower than that of wild-type control mice. The ACE 1/3 mice demonstrate the plasticity of the RAS and show that significant compensation is required to maintain normal, basal blood pressure in a mouse with an impaired local vascular and renal RAS."xsd:string |
| http://purl.uniprot.org/citations/12574101 | http://purl.org/dc/terms/identifier | "doi:10.1161/01.hyp.0000050650.52007.83"xsd:string |
| http://purl.uniprot.org/citations/12574101 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
| http://purl.uniprot.org/citations/12574101 | http://purl.uniprot.org/core/author | "Capecchi M.R."xsd:string |
| http://purl.uniprot.org/citations/12574101 | http://purl.uniprot.org/core/author | "Adams J.W."xsd:string |
| http://purl.uniprot.org/citations/12574101 | http://purl.uniprot.org/core/author | "Bernstein K.E."xsd:string |
| http://purl.uniprot.org/citations/12574101 | http://purl.uniprot.org/core/author | "Cole J.M."xsd:string |
| http://purl.uniprot.org/citations/12574101 | http://purl.uniprot.org/core/author | "Corvol P."xsd:string |
| http://purl.uniprot.org/citations/12574101 | http://purl.uniprot.org/core/author | "Sutliff R.L."xsd:string |
| http://purl.uniprot.org/citations/12574101 | http://purl.uniprot.org/core/author | "Khokhlova N."xsd:string |
| http://purl.uniprot.org/citations/12574101 | http://purl.uniprot.org/core/author | "Disher K.M."xsd:string |
| http://purl.uniprot.org/citations/12574101 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12574101 | http://purl.uniprot.org/core/name | "Hypertension"xsd:string |
| http://purl.uniprot.org/citations/12574101 | http://purl.uniprot.org/core/pages | "313-321"xsd:string |
| http://purl.uniprot.org/citations/12574101 | http://purl.uniprot.org/core/title | "Mice lacking endothelial ACE: normal blood pressure with elevated angiotensin II."xsd:string |
| http://purl.uniprot.org/citations/12574101 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/12574101 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12574101 |
| http://purl.uniprot.org/citations/12574101 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12574101 |
| http://purl.uniprot.org/uniprot/#_F6QCP8-mappedCitation-12574101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12574101 |
| http://purl.uniprot.org/uniprot/#_Q3TU20-mappedCitation-12574101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12574101 |
| http://purl.uniprot.org/uniprot/#_P09470-mappedCitation-12574101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12574101 |
| http://purl.uniprot.org/uniprot/#_Q5XK22-mappedCitation-12574101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12574101 |
| http://purl.uniprot.org/uniprot/#_Q3U3Q7-mappedCitation-12574101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12574101 |
| http://purl.uniprot.org/uniprot/#_Q7TSV8-mappedCitation-12574101 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12574101 |