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http://purl.uniprot.org/citations/12576453http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12576453http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

Metastatic renal cell carcinoma (RCC) has a poor prognosis and an unpredictable course. To date, there are no molecular markers which can reliably predict RCC outcome. We investigated whether a novel kidney cancer marker, carbonic anhydrase IX (CAIX), is associated with progression and survival.

Experimental design

Immunohistochemical analysis using a CAIX monoclonal antibody was performed on tissue microarrays constructed from paraffin-embedded specimens from patients (N = 321) treated by nephrectomy for clear cell RCC. CAIX staining was correlated with response to treatment, clinical factors, pathologic features, and survival.

Results

CAIX staining was present in 94% of clear cell RCCs. Survival tree analysis determined that a cutoff of 85% CAIX staining provided the most accurate prediction of survival. Low CAIX (ConclusionsOn the basis of our data, CAIX is the most significant molecular marker described in kidney cancer to date. Decreased CAIX levels are independently associated with poor survival in advanced RCC. CAIX reflects significant changes in tumor biology, which should be used to predict clinical outcome and identify high-risk patients in need for adjuvant immunotherapy and CAIX-targeted therapies."xsd:string
http://purl.uniprot.org/citations/12576453http://purl.uniprot.org/core/author"Huang Y."xsd:string
http://purl.uniprot.org/citations/12576453http://purl.uniprot.org/core/author"Chopra S."xsd:string
http://purl.uniprot.org/citations/12576453http://purl.uniprot.org/core/author"Lerman M.I."xsd:string
http://purl.uniprot.org/citations/12576453http://purl.uniprot.org/core/author"Palotie A."xsd:string
http://purl.uniprot.org/citations/12576453http://purl.uniprot.org/core/author"Liao S.Y."xsd:string
http://purl.uniprot.org/citations/12576453http://purl.uniprot.org/core/author"Bui M.H."xsd:string
http://purl.uniprot.org/citations/12576453http://purl.uniprot.org/core/author"Horvath S."xsd:string
http://purl.uniprot.org/citations/12576453http://purl.uniprot.org/core/author"Stanbridge E."xsd:string
http://purl.uniprot.org/citations/12576453http://purl.uniprot.org/core/author"Leibovich B.C."xsd:string
http://purl.uniprot.org/citations/12576453http://purl.uniprot.org/core/author"Han K.R."xsd:string
http://purl.uniprot.org/citations/12576453http://purl.uniprot.org/core/author"Belldegrun A.S."xsd:string
http://purl.uniprot.org/citations/12576453http://purl.uniprot.org/core/author"Dorey F.J."xsd:string
http://purl.uniprot.org/citations/12576453http://purl.uniprot.org/core/author"Figlin R.A."xsd:string
http://purl.uniprot.org/citations/12576453http://purl.uniprot.org/core/author"Pantuck A.J."xsd:string
http://purl.uniprot.org/citations/12576453http://purl.uniprot.org/core/author"Seligson D."xsd:string
http://purl.uniprot.org/citations/12576453http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12576453http://purl.uniprot.org/core/name"Clin Cancer Res"xsd:string
http://purl.uniprot.org/citations/12576453http://purl.uniprot.org/core/pages"802-811"xsd:string
http://purl.uniprot.org/citations/12576453http://purl.uniprot.org/core/title"Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy."xsd:string
http://purl.uniprot.org/citations/12576453http://purl.uniprot.org/core/volume"9"xsd:string
http://purl.uniprot.org/citations/12576453http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12576453
http://purl.uniprot.org/citations/12576453http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12576453
http://purl.uniprot.org/uniprot/#_A0A0S2Z341-mappedCitation-12576453http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12576453
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