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http://purl.uniprot.org/citations/12577052http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12577052http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12577052http://www.w3.org/2000/01/rdf-schema#comment"The calmodulin-binding domain of myristoylated alanine-rich C kinase substrate (MARCKS), which interacts with various targets including calmodulin, actin and membrane lipids, has been suggested to function as a crosstalk point among several signal transduction pathways. We present here the crystal structure at 2 A resolution of a peptide consisting of the MARCKS calmodulin (CaM)-binding domain in complex with Ca2+-CaM. The domain assumes a flexible conformation, and the hydrophobic pocket of the calmodulin N-lobe, which is a common CaM-binding site observed in previously resolved Ca2+-CaM-target peptide complexes, is not involved in the interaction. The present structure presents a novel target-recognition mode of calmodulin and provides insight into the structural basis of the flexible interaction module of MARCKS."xsd:string
http://purl.uniprot.org/citations/12577052http://purl.org/dc/terms/identifier"doi:10.1038/nsb900"xsd:string
http://purl.uniprot.org/citations/12577052http://purl.org/dc/terms/identifier"doi:10.1038/nsb900"xsd:string
http://purl.uniprot.org/citations/12577052http://purl.uniprot.org/core/author"Kato H."xsd:string
http://purl.uniprot.org/citations/12577052http://purl.uniprot.org/core/author"Kato H."xsd:string
http://purl.uniprot.org/citations/12577052http://purl.uniprot.org/core/author"Taniguchi H."xsd:string
http://purl.uniprot.org/citations/12577052http://purl.uniprot.org/core/author"Taniguchi H."xsd:string
http://purl.uniprot.org/citations/12577052http://purl.uniprot.org/core/author"Nakatsu T."xsd:string
http://purl.uniprot.org/citations/12577052http://purl.uniprot.org/core/author"Nakatsu T."xsd:string
http://purl.uniprot.org/citations/12577052http://purl.uniprot.org/core/author"Matsubara M."xsd:string
http://purl.uniprot.org/citations/12577052http://purl.uniprot.org/core/author"Matsubara M."xsd:string
http://purl.uniprot.org/citations/12577052http://purl.uniprot.org/core/author"Yamauchi E."xsd:string
http://purl.uniprot.org/citations/12577052http://purl.uniprot.org/core/author"Yamauchi E."xsd:string
http://purl.uniprot.org/citations/12577052http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12577052http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12577052http://purl.uniprot.org/core/name"Nat. Struct. Biol."xsd:string
http://purl.uniprot.org/citations/12577052http://purl.uniprot.org/core/name"Nat. Struct. Biol."xsd:string
http://purl.uniprot.org/citations/12577052http://purl.uniprot.org/core/pages"226-231"xsd:string
http://purl.uniprot.org/citations/12577052http://purl.uniprot.org/core/pages"226-231"xsd:string
http://purl.uniprot.org/citations/12577052http://purl.uniprot.org/core/title"Crystal structure of a MARCKS peptide containing the calmodulin-binding domain in complex with Ca2+-calmodulin."xsd:string
http://purl.uniprot.org/citations/12577052http://purl.uniprot.org/core/title"Crystal structure of a MARCKS peptide containing the calmodulin-binding domain in complex with Ca2+-calmodulin."xsd:string
http://purl.uniprot.org/citations/12577052http://purl.uniprot.org/core/volume"10"xsd:string
http://purl.uniprot.org/citations/12577052http://purl.uniprot.org/core/volume"10"xsd:string