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http://purl.uniprot.org/citations/12579508http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Objective

To assess the associations between schizophrenia and six functional genes: dopamine D2 receptor gene (DRD2), dopamine D4 receptor gene (DRD4), 5-hydroxytryptamine 2A receptor gene (5-HT2A), 5-HT6 receptor gene (5-HT6), catechol-O-methyltransferase gene (COMT) and dopamine transporter gene (DAT1).

Methods

With the techniques of Amp-RFLP and Amp-FLP, association analysis was made between schizophrenia and the six genes in 67 schizophrenic patients from Chinese Han population.

Results

(1) Neither genotypes nor alleles of DRD2, 5-HT2A, 5-HT6 and COMT gene showed significant differences between patients and controls (P>0.05). (2) Six repeats (6R) in DRD4 gene, the allele of 480 bp and the genotype of 480/520 in DAT1 gene were found to be of significant differences between the two groups (P<0.05). (3) Only one negative association was observed between the 480 bp allele of DAT1 gene and schizophrenia (OR=0.441, 95% CI:0.202-0.963, Z=2.05, P<0.05).

Conclusion

The 480 bp allele of DAT1 gene is negatively associated with schizophrenia in Chinese Han population, which stands for the dopamine hypothesis of schizophrenia."xsd:string
http://purl.uniprot.org/citations/12579508http://purl.uniprot.org/core/author"Huang Y.P."xsd:string
http://purl.uniprot.org/citations/12579508http://purl.uniprot.org/core/author"Qian Y.C."xsd:string
http://purl.uniprot.org/citations/12579508http://purl.uniprot.org/core/author"Zhang X."xsd:string
http://purl.uniprot.org/citations/12579508http://purl.uniprot.org/core/author"Ji Q."xsd:string
http://purl.uniprot.org/citations/12579508http://purl.uniprot.org/core/author"Zhang M.L."xsd:string
http://purl.uniprot.org/citations/12579508http://purl.uniprot.org/core/author"Yao J.J."xsd:string
http://purl.uniprot.org/citations/12579508http://purl.uniprot.org/core/author"Tang R.C."xsd:string
http://purl.uniprot.org/citations/12579508http://purl.uniprot.org/core/author"Jiang S.D."xsd:string
http://purl.uniprot.org/citations/12579508http://purl.uniprot.org/core/author"Yuan G.Z."xsd:string
http://purl.uniprot.org/citations/12579508http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12579508http://purl.uniprot.org/core/name"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/12579508http://purl.uniprot.org/core/pages"69-71"xsd:string
http://purl.uniprot.org/citations/12579508http://purl.uniprot.org/core/title"[Associations between six functional genes and schizophrenia]."xsd:string
http://purl.uniprot.org/citations/12579508http://purl.uniprot.org/core/volume"20"xsd:string
http://purl.uniprot.org/citations/12579508http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12579508
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