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Objective

To investigate the predisposing role of HLA-DRB1, DQB1 genes in pemphigus vulgaris (PV).

Methods

Polymerase chain reaction-specific sequence primers method was used to type HLA-DRB1, DQB1 subregion in the patients with PV of Han nationality from Jiangsu and Anhui provinces and matched control subjects.

Results

DR4, DRB1*14(*1401,*1404,*1405) gene frequencies in PV patients were significantly higher than those in controls (Pc<0.05 and Pc<0.01 respectively). DQB1*0302, DQB1*0503 gene frequencies were significantly higher in PV patients (Pc<0.05). Further typing of DR4 positive subjects revealed that the gene frequencies of DRB1*0406, *0403 were significantly increased in PV patients as compared with controls (Pc<0.05). The haplotype frequencies of HLA-DRB1*04, DQB1*0302 and HLA-DRB1*14, DQB1*0503 in PV patients were significantly higher than those in controls (P<0.05).

Conclusion

The results suggest that the combination of HLA-DRB1*4, DQB1*0302 and HLA-DRB1*14, DQB1*0503 forms putative susceptible haplotypes for PV patients in Chinese Hans."xsd:string
http://purl.uniprot.org/citations/12579512http://purl.uniprot.org/core/author"Lin L."xsd:string
http://purl.uniprot.org/citations/12579512http://purl.uniprot.org/core/author"Zhou S.H."xsd:string
http://purl.uniprot.org/citations/12579512http://purl.uniprot.org/core/author"Jin P.Y."xsd:string
http://purl.uniprot.org/citations/12579512http://purl.uniprot.org/core/author"Ye S.Z."xsd:string
http://purl.uniprot.org/citations/12579512http://purl.uniprot.org/core/date"2003"xsd:gYear
http://purl.uniprot.org/citations/12579512http://purl.uniprot.org/core/name"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/12579512http://purl.uniprot.org/core/pages"79-81"xsd:string
http://purl.uniprot.org/citations/12579512http://purl.uniprot.org/core/title"[Association between HLA-DRB1, DQB1 genes and pemphigus vulgaris in Chinese Hans]."xsd:string
http://purl.uniprot.org/citations/12579512http://purl.uniprot.org/core/volume"20"xsd:string
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