| http://purl.uniprot.org/citations/12582207 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12582207 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12582207 | http://www.w3.org/2000/01/rdf-schema#comment | "Beta-arrestins bind to activated G protein-coupled receptor kinase-phosphorylated receptors, which leads to their desensitization with respect to G proteins, internalization via clathrin-coated pits, and signaling via a growing list of "scaffolded" pathways. To facilitate the discovery of novel adaptor and signaling roles of beta-arrestins, we have developed and validated a generally applicable interfering RNA approach for selectively suppressing beta-arrestins 1 or 2 expression by up to 95%. Beta-arrestin depletion in HEK293 cells leads to enhanced cAMP generation in response to beta(2)-adrenergic receptor stimulation, markedly reduced beta(2)-adrenergic receptor and angiotensin II receptor internalization and impaired activation of the MAP kinases ERK 1 and 2 by angiotensin II. This approach should allow discovery of novel signaling and regulatory roles for the beta-arrestins in many seven-membrane-spanning receptor systems."xsd:string |
| http://purl.uniprot.org/citations/12582207 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.262789099"xsd:string |
| http://purl.uniprot.org/citations/12582207 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.262789099"xsd:string |
| http://purl.uniprot.org/citations/12582207 | http://purl.uniprot.org/core/author | "Lefkowitz R.J."xsd:string |
| http://purl.uniprot.org/citations/12582207 | http://purl.uniprot.org/core/author | "Lefkowitz R.J."xsd:string |
| http://purl.uniprot.org/citations/12582207 | http://purl.uniprot.org/core/author | "Nelson C.D."xsd:string |
| http://purl.uniprot.org/citations/12582207 | http://purl.uniprot.org/core/author | "Nelson C.D."xsd:string |
| http://purl.uniprot.org/citations/12582207 | http://purl.uniprot.org/core/author | "Ahn S."xsd:string |
| http://purl.uniprot.org/citations/12582207 | http://purl.uniprot.org/core/author | "Ahn S."xsd:string |
| http://purl.uniprot.org/citations/12582207 | http://purl.uniprot.org/core/author | "Miller W.E."xsd:string |
| http://purl.uniprot.org/citations/12582207 | http://purl.uniprot.org/core/author | "Miller W.E."xsd:string |
| http://purl.uniprot.org/citations/12582207 | http://purl.uniprot.org/core/author | "Garrison T.R."xsd:string |
| http://purl.uniprot.org/citations/12582207 | http://purl.uniprot.org/core/author | "Garrison T.R."xsd:string |
| http://purl.uniprot.org/citations/12582207 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12582207 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12582207 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/12582207 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/12582207 | http://purl.uniprot.org/core/pages | "1740-1744"xsd:string |
| http://purl.uniprot.org/citations/12582207 | http://purl.uniprot.org/core/pages | "1740-1744"xsd:string |
| http://purl.uniprot.org/citations/12582207 | http://purl.uniprot.org/core/title | "Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference."xsd:string |
| http://purl.uniprot.org/citations/12582207 | http://purl.uniprot.org/core/title | "Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference."xsd:string |
| http://purl.uniprot.org/citations/12582207 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/12582207 | http://purl.uniprot.org/core/volume | "100"xsd:string |