| http://purl.uniprot.org/citations/12584049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12584049 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-2 therapy is an immune-based treatment for HIV-1-infected individuals with declining CD4(+) T cell counts. Intravenous IL-2 produces an elevation of circulating CD4(+) T cells, but with a varying degree of effectiveness in individual patients. IL-2 is also known to increase the expression of chemokine receptors, coreceptors for HIV-1. Allelic variation in chemokine receptor genes can markedly affect the course of HIV disease; consequently, we analyzed CCR5 and CCR2B genotypes among a cohort of HIV-1-infected individuals that received IL-2 therapy. DNA was extracted from treated individuals and genotyping was performed using PCR followed by allele-specific detection or cleavage of the amplified product. Samples from 47 trial participants (25 CIV-IL-2 group; 22 placebo group) were analyzed for CCR5 and CCR2B genotype. We report that CCR5 Delta 32 heterozygous individuals had a greater CD4(+) T cell response to continuous intravenous IL-2 (CIV-IL-2) treatment than those homozygous for the wild-type allele (median = 427 vs 237 cells/mm(3); P = 0.03). This study highlights the importance of interactions between IL-2 and CCR5; at the clinical level, it argues for assessment of chemokine receptor genotype in IL-2 and perhaps other immune-based therapy trials."xsd:string |
| http://purl.uniprot.org/citations/12584049 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1521-6616(02)00020-7"xsd:string |
| http://purl.uniprot.org/citations/12584049 | http://purl.uniprot.org/core/author | "Cooper D."xsd:string |
| http://purl.uniprot.org/citations/12584049 | http://purl.uniprot.org/core/author | "Stewart G."xsd:string |
| http://purl.uniprot.org/citations/12584049 | http://purl.uniprot.org/core/author | "Williamson P."xsd:string |
| http://purl.uniprot.org/citations/12584049 | http://purl.uniprot.org/core/author | "Carr A."xsd:string |
| http://purl.uniprot.org/citations/12584049 | http://purl.uniprot.org/core/author | "Emery S."xsd:string |
| http://purl.uniprot.org/citations/12584049 | http://purl.uniprot.org/core/author | "Biti R."xsd:string |
| http://purl.uniprot.org/citations/12584049 | http://purl.uniprot.org/core/author | "Clegg A."xsd:string |
| http://purl.uniprot.org/citations/12584049 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12584049 | http://purl.uniprot.org/core/name | "Clin Immunol"xsd:string |
| http://purl.uniprot.org/citations/12584049 | http://purl.uniprot.org/core/pages | "36-40"xsd:string |
| http://purl.uniprot.org/citations/12584049 | http://purl.uniprot.org/core/title | "Chemokine receptor genotype and response to interleukin-2 therapy in HIV-1-infected individuals."xsd:string |
| http://purl.uniprot.org/citations/12584049 | http://purl.uniprot.org/core/volume | "106"xsd:string |
| http://purl.uniprot.org/citations/12584049 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12584049 |
| http://purl.uniprot.org/citations/12584049 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12584049 |
| http://purl.uniprot.org/uniprot/#_A0A089G6S9-mappedCitation-12584049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12584049 |
| http://purl.uniprot.org/uniprot/#_A0A089G7F7-mappedCitation-12584049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12584049 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G0-mappedCitation-12584049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12584049 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G7-mappedCitation-12584049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12584049 |
| http://purl.uniprot.org/uniprot/#_A0A089G7G9-mappedCitation-12584049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12584049 |
| http://purl.uniprot.org/uniprot/#_A0A089G3J8-mappedCitation-12584049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12584049 |
| http://purl.uniprot.org/uniprot/#_A0A089G3K0-mappedCitation-12584049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12584049 |
| http://purl.uniprot.org/uniprot/#_A0A089G3N4-mappedCitation-12584049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12584049 |