| http://purl.uniprot.org/citations/12584329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12584329 | http://www.w3.org/2000/01/rdf-schema#comment | "Human immunodeficiency virus type 1 (HIV-1) Nef is a key pathogenic factor necessary for the development of AIDS. One important function of Nef is to reduce cell surface levels of major histocompatibility complex class I (MHC-I) molecules, thereby protecting HIV-infected cells from recognition by cytotoxic T lymphocytes. The mechanism of MHC-I downmodulation by Nef has not been clearly elucidated, and its reported effect on MHC-I steady-state levels ranges widely, from 2-fold in HeLa cells to 200-fold in HIV-infected primary T cells. Here, we directly compared downmodulation of HLA-A2 in HIV-infected HeLa cells to that in T cells. We found that similar amounts of Nef protein resulted in a much more dramatic downmodulation of HLA-A2 in T cells than in HeLa cells. A comparison of Nef's effects on HLA-A2 endocytosis, recycling, and transport rates indicated that the most prominent effect of Nef on HLA-A2 in T cells was to inhibit transport to the cell surface. The phosphatidylinositol 3-kinase inhibitor, LY294002, previously reported to inhibit Nef-mediated MHC-I downmodulation in astrocytic cells, did not directly affect Nef's ability to block transport of MHC-I to the cell surface in T cells."xsd:string |
| http://purl.uniprot.org/citations/12584329 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.77.5.3041-3049.2003"xsd:string |
| http://purl.uniprot.org/citations/12584329 | http://purl.uniprot.org/core/author | "Collins K.L."xsd:string |
| http://purl.uniprot.org/citations/12584329 | http://purl.uniprot.org/core/author | "Kasper M.R."xsd:string |
| http://purl.uniprot.org/citations/12584329 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12584329 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/12584329 | http://purl.uniprot.org/core/pages | "3041-3049"xsd:string |
| http://purl.uniprot.org/citations/12584329 | http://purl.uniprot.org/core/title | "Nef-mediated disruption of HLA-A2 transport to the cell surface in T cells."xsd:string |
| http://purl.uniprot.org/citations/12584329 | http://purl.uniprot.org/core/volume | "77"xsd:string |
| http://purl.uniprot.org/citations/12584329 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12584329 |
| http://purl.uniprot.org/citations/12584329 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12584329 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-12584329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12584329 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-12584329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12584329 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N3-mappedCitation-12584329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12584329 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N4-mappedCitation-12584329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12584329 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N5-mappedCitation-12584329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12584329 |
| http://purl.uniprot.org/uniprot/#_A0A076JXB7-mappedCitation-12584329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12584329 |
| http://purl.uniprot.org/uniprot/#_A0A076L0P9-mappedCitation-12584329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12584329 |
| http://purl.uniprot.org/uniprot/#_A0A0A0YLW6-mappedCitation-12584329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12584329 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C7I7-mappedCitation-12584329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12584329 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C852-mappedCitation-12584329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12584329 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C857-mappedCitation-12584329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12584329 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C8P7-mappedCitation-12584329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12584329 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC65-mappedCitation-12584329 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12584329 |