| http://purl.uniprot.org/citations/12584359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12584359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12584359 | http://www.w3.org/2000/01/rdf-schema#comment | "Ebola virus VP30 is an essential activator of viral transcription. In viral particles, VP30 is closely associated with the nucleocapsid complex. A conspicuous structural feature of VP30 is an unconventional zinc-binding Cys(3)-His motif comprising amino acids 68 to 95. By using a colorimetric zinc-binding assay we found that the VP30-specific Cys(3)-His motif stoichiometrically binds zinc ions in a one-to-one relationship. Substitution of the conserved cysteines and the histidine within the motif led to a complete loss of the capacity for zinc binding. Functional analyses revealed that none of the tested mutations of the proposed zinc-coordinating residues influenced binding of VP30 to nucleocapsid-like particles but, concerning its role in activating viral transcription, all resulted in a protein that was inactive."xsd:string |
| http://purl.uniprot.org/citations/12584359 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.77.5.3334-3338.2003"xsd:string |
| http://purl.uniprot.org/citations/12584359 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.77.5.3334-3338.2003"xsd:string |
| http://purl.uniprot.org/citations/12584359 | http://purl.uniprot.org/core/author | "Becker S."xsd:string |
| http://purl.uniprot.org/citations/12584359 | http://purl.uniprot.org/core/author | "Becker S."xsd:string |
| http://purl.uniprot.org/citations/12584359 | http://purl.uniprot.org/core/author | "Modrof J."xsd:string |
| http://purl.uniprot.org/citations/12584359 | http://purl.uniprot.org/core/author | "Modrof J."xsd:string |
| http://purl.uniprot.org/citations/12584359 | http://purl.uniprot.org/core/author | "Muhlberger E."xsd:string |
| http://purl.uniprot.org/citations/12584359 | http://purl.uniprot.org/core/author | "Muhlberger E."xsd:string |
| http://purl.uniprot.org/citations/12584359 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12584359 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12584359 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/12584359 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/12584359 | http://purl.uniprot.org/core/pages | "3334-3338"xsd:string |
| http://purl.uniprot.org/citations/12584359 | http://purl.uniprot.org/core/pages | "3334-3338"xsd:string |
| http://purl.uniprot.org/citations/12584359 | http://purl.uniprot.org/core/title | "Ebola virus transcription activator VP30 is a zinc-binding protein."xsd:string |
| http://purl.uniprot.org/citations/12584359 | http://purl.uniprot.org/core/title | "Ebola virus transcription activator VP30 is a zinc-binding protein."xsd:string |
| http://purl.uniprot.org/citations/12584359 | http://purl.uniprot.org/core/volume | "77"xsd:string |
| http://purl.uniprot.org/citations/12584359 | http://purl.uniprot.org/core/volume | "77"xsd:string |
| http://purl.uniprot.org/citations/12584359 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12584359 |
| http://purl.uniprot.org/citations/12584359 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12584359 |
| http://purl.uniprot.org/citations/12584359 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12584359 |
| http://purl.uniprot.org/citations/12584359 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12584359 |