| http://purl.uniprot.org/citations/12585965 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12585965 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12585965 | http://www.w3.org/2000/01/rdf-schema#comment | "The location of sarco/endoplasmic-reticulum calcium ATPase (SERCA) retention/retrieval motifs in the sequence of the SERCA1 has been investigated by examining the subcellular location in COS-7 cells of enhanced-green-fluorescent-protein-tagged calcium-pump chimaeras. These chimaeras have been constructed from the fast-twitch SERCA1 and the plasma-membrane calcium ATPase PMCA3. The N-terminal, central and C-terminal segments of these calcium pumps were exchanged between SERCA1 and PMCA3. The segments exchanged correspond to residues 1-211, 212-711 and 712-994 of SERCA1, and residues 1-264, 265-788 and 789-1159 of PMCA3 respectively. Only chimaeras containing the N-terminal segment of SERCA1 were located in the endoplasmic reticulum (ER), whereas chimaeras containing the N-terminal segment from PMCA3 were able to escape from the ER and enter the endomembrane pathway en route for the plasma membrane. Co-localization of SERCA1 in COS-7 cells with the ER/Golgi-intermediate compartment marker ERGIC53 indicates that SERCA1 is maintained in the ER by a process of retrieval. These results indicate that the N-terminal region of SERCA1, containing transmembrane helices M1 and M2, contains an ER-retrieval signal."xsd:string |
| http://purl.uniprot.org/citations/12585965 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20021477"xsd:string |
| http://purl.uniprot.org/citations/12585965 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20021477"xsd:string |
| http://purl.uniprot.org/citations/12585965 | http://purl.uniprot.org/core/author | "Butler J."xsd:string |
| http://purl.uniprot.org/citations/12585965 | http://purl.uniprot.org/core/author | "Butler J."xsd:string |
| http://purl.uniprot.org/citations/12585965 | http://purl.uniprot.org/core/author | "East J.M."xsd:string |
| http://purl.uniprot.org/citations/12585965 | http://purl.uniprot.org/core/author | "East J.M."xsd:string |
| http://purl.uniprot.org/citations/12585965 | http://purl.uniprot.org/core/author | "Chad J."xsd:string |
| http://purl.uniprot.org/citations/12585965 | http://purl.uniprot.org/core/author | "Chad J."xsd:string |
| http://purl.uniprot.org/citations/12585965 | http://purl.uniprot.org/core/author | "Black J.P."xsd:string |
| http://purl.uniprot.org/citations/12585965 | http://purl.uniprot.org/core/author | "Black J.P."xsd:string |
| http://purl.uniprot.org/citations/12585965 | http://purl.uniprot.org/core/author | "Lee A.G."xsd:string |
| http://purl.uniprot.org/citations/12585965 | http://purl.uniprot.org/core/author | "Lee A.G."xsd:string |
| http://purl.uniprot.org/citations/12585965 | http://purl.uniprot.org/core/author | "Newton T."xsd:string |
| http://purl.uniprot.org/citations/12585965 | http://purl.uniprot.org/core/author | "Newton T."xsd:string |
| http://purl.uniprot.org/citations/12585965 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12585965 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12585965 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/12585965 | http://purl.uniprot.org/core/name | "Biochem. J."xsd:string |
| http://purl.uniprot.org/citations/12585965 | http://purl.uniprot.org/core/pages | "775-782"xsd:string |
| http://purl.uniprot.org/citations/12585965 | http://purl.uniprot.org/core/pages | "775-782"xsd:string |
| http://purl.uniprot.org/citations/12585965 | http://purl.uniprot.org/core/title | "Sarco/endoplasmic-reticulum calcium ATPase SERCA1 is maintained in the endoplasmic reticulum by a retrieval signal located between residues 1 and 211."xsd:string |
| http://purl.uniprot.org/citations/12585965 | http://purl.uniprot.org/core/title | "Sarco/endoplasmic-reticulum calcium ATPase SERCA1 is maintained in the endoplasmic reticulum by a retrieval signal located between residues 1 and 211."xsd:string |