| http://purl.uniprot.org/citations/12585966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12585966 | http://www.w3.org/2000/01/rdf-schema#comment | "Platelet adhesion on von Willebrand factor (vWf) requires the co-ordinated adhesive function of glycoprotein Ib/V/IX and integrin alphaIIbbeta3. Recent evidence [Nesbitt, Kulkarni, Giuliano, Gonclaves, Dopheide, Yap, Harper, Salem and Jackson (2002) J. Biol. Chem. 277, 2965-2972] suggests that outside-in signals from both receptors play important roles in regulating platelet-adhesion dynamics under flow. In the present study, we have examined the mechanisms utilized by protein kinase C (PKC) to promote irreversible platelet adhesion on vWf. We demonstrate that PKC is primarily activated downstream of integrin alphaIIbbeta3, not glycoprotein Ib, during platelet adhesion on vWf. This integrin alphaIIbbeta3-dependent PKC activation establishes a positive-feedback loop that promotes further integrin alphaIIbbeta3 activation, calcium mobilization and firm platelet adhesion. This feedback loop appears to be most relevant at relatively low cytosolic calcium concentrations (mean Delta[Ca(2+)](i);100 nM) as artificially elevating calcium (mean Delta[Ca(2+)](i) > 500 nM) induces integrin alphaIIbbeta3 activation and irreversible platelet adhesion independent of PKC. Our studies demonstrate the existence of a complex signalling relationship operating between PKC, cytosolic calcium and integrin alphaIIbbeta3 that serves to regulate platelet-adhesion dynamics under flow. Furthermore, we have established the existence of PKC-dependent and -independent pathways regulating integrin alphaIIbbeta3 activation and stable platelet adhesion on vWf."xsd:string |
| http://purl.uniprot.org/citations/12585966 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20020868"xsd:string |
| http://purl.uniprot.org/citations/12585966 | http://purl.uniprot.org/core/author | "Jackson S.P."xsd:string |
| http://purl.uniprot.org/citations/12585966 | http://purl.uniprot.org/core/author | "Giuliano S."xsd:string |
| http://purl.uniprot.org/citations/12585966 | http://purl.uniprot.org/core/author | "Nesbitt W.S."xsd:string |
| http://purl.uniprot.org/citations/12585966 | http://purl.uniprot.org/core/author | "Rooney M."xsd:string |
| http://purl.uniprot.org/citations/12585966 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12585966 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/12585966 | http://purl.uniprot.org/core/pages | "163-172"xsd:string |
| http://purl.uniprot.org/citations/12585966 | http://purl.uniprot.org/core/title | "Bidirectional integrin alphaIIbbeta3 signalling regulating platelet adhesion under flow: contribution of protein kinase C."xsd:string |
| http://purl.uniprot.org/citations/12585966 | http://purl.uniprot.org/core/volume | "372"xsd:string |
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