| http://purl.uniprot.org/citations/12586062 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12586062 | http://www.w3.org/2000/01/rdf-schema#comment | "The JAK/STAT signal transduction pathway regulates many developmental processes in Drosophila. However, the functional mechanism of this pathway is poorly understood. In this report, we identify the Drosophila cyclin-dependent kinase 4 (Cdk4), which exhibits embryonic mutant phenotypes identical to those in the Hopscotch/JAK kinase and stat92E/STAT mutations. Specific genetic interactions between Cdk4 and hop mutations suggest that Cdk4 functions downstream of the HOP tyrosine kinase. We further show that Cyclin D-Cdk4 (as well as Cyclin E-Cdk2) binds and regulates STAT92E protein stability. STAT92E regulates gene expression for various biological processes, including the endocycle S phase. These data suggest that Cyclin D-Cdk4 and Cyclin E-Cdk2 play more versatile roles in Drosophila development."xsd:string |
| http://purl.uniprot.org/citations/12586062 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1534-5807(03)00024-8"xsd:string |
| http://purl.uniprot.org/citations/12586062 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/12586062 | http://purl.uniprot.org/core/author | "Zheng Z."xsd:string |
| http://purl.uniprot.org/citations/12586062 | http://purl.uniprot.org/core/author | "Chen H.W."xsd:string |
| http://purl.uniprot.org/citations/12586062 | http://purl.uniprot.org/core/author | "Hou S.X."xsd:string |
| http://purl.uniprot.org/citations/12586062 | http://purl.uniprot.org/core/author | "Oh S.W."xsd:string |
| http://purl.uniprot.org/citations/12586062 | http://purl.uniprot.org/core/author | "Shin H.H."xsd:string |
| http://purl.uniprot.org/citations/12586062 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12586062 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/12586062 | http://purl.uniprot.org/core/pages | "179-190"xsd:string |
| http://purl.uniprot.org/citations/12586062 | http://purl.uniprot.org/core/title | "Cyclin D-Cdk4 and cyclin E-Cdk2 regulate the Jak/STAT signal transduction pathway in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/12586062 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/12586062 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12586062 |
| http://purl.uniprot.org/citations/12586062 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12586062 |
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| http://purl.uniprot.org/uniprot/P23573#attribution-39895D5DDF44A0C6655D08565B347AA9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12586062 |
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