| http://purl.uniprot.org/citations/12593856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12593856 | http://www.w3.org/2000/01/rdf-schema#comment | "Previously, we have shown that over-expression of either E2F1 or c-Myc promotes hepatocarcinogenesis and that E2F1 mice acquire HCC more rapidly than c-Myc transgenic mice. We also found that co-expression of E2F1/c-Myc further accelerates liver cancer development. Here we describe that the deregulated expression of these two transcription factors also affects hepatic ploidy during post-natal liver growth and before the onset of tumors. Oncogenic activity of E2F1 and/or c-Myc was associated with a persistent increase in hepatocyte proliferation. However, E2F1-mediated cell proliferation favored the predominance of diploid cells characteristic of pre-neoplastic type of liver growth whereas c-Myc functioned to accelerate age-related hepatocyte polyploidization. Similarly, proliferative advantage conferred by co-expression of E2F1 and c-Myc increased the frequency of diploid cells at a young age. Thus, the opposing effects of E2F1 and c-Myc on hepatocyte ploidy suggest that these two transcription factors have different mechanisms by which they control liver proliferation/maturation and ultimately, carcinogenesis."xsd:string |
| http://purl.uniprot.org/citations/12593856 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(03)00125-6"xsd:string |
| http://purl.uniprot.org/citations/12593856 | http://purl.uniprot.org/core/author | "Sanchez A."xsd:string |
| http://purl.uniprot.org/citations/12593856 | http://purl.uniprot.org/core/author | "Thorgeirsson S.S."xsd:string |
| http://purl.uniprot.org/citations/12593856 | http://purl.uniprot.org/core/author | "Factor V.M."xsd:string |
| http://purl.uniprot.org/citations/12593856 | http://purl.uniprot.org/core/author | "Lemmer E.R."xsd:string |
| http://purl.uniprot.org/citations/12593856 | http://purl.uniprot.org/core/author | "Conner E.A."xsd:string |
| http://purl.uniprot.org/citations/12593856 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12593856 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/12593856 | http://purl.uniprot.org/core/pages | "114-120"xsd:string |
| http://purl.uniprot.org/citations/12593856 | http://purl.uniprot.org/core/title | "E2F1 blocks and c-Myc accelerates hepatic ploidy in transgenic mouse models."xsd:string |
| http://purl.uniprot.org/citations/12593856 | http://purl.uniprot.org/core/volume | "302"xsd:string |
| http://purl.uniprot.org/citations/12593856 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12593856 |
| http://purl.uniprot.org/citations/12593856 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12593856 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YTX7-mappedCitation-12593856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12593856 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YU11-mappedCitation-12593856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12593856 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YU48-mappedCitation-12593856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12593856 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUI9-mappedCitation-12593856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12593856 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUK2-mappedCitation-12593856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12593856 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUW7-mappedCitation-12593856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12593856 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUX8-mappedCitation-12593856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12593856 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YV00-mappedCitation-12593856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12593856 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YV21-mappedCitation-12593856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12593856 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YV59-mappedCitation-12593856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12593856 |