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| http://purl.uniprot.org/citations/12594267 | http://www.w3.org/2000/01/rdf-schema#comment | "The B cell lymphoma (BCL)-6 transcriptional repressor protein is an important regulator of Th2 responses. Mice deficient in BCL-6 develop severe Th2-type inflammation that can develop even in the absence of IL-4 signaling. We have investigated the mechanism for how BCL-6 regulates Th2 cell differentiation and have found that IL-6 signaling can promote dramatically increased levels of Th2 differentiation in BCL-6(-/-) CD4 T cells compared with wild-type CD4 T cells. IL-6 can induce a low level of Th2 cytokine expression in BCL-6(-/-)STAT6(-/-) cells but not in STAT6(-/-) cells. Since the promoters for Th2 cytokines such as IL-4, IL-5, IL-10, and IL-13 do not contain consensus BCL-6 DNA binding sites, we investigated whether BCL-6 might regulate the GATA-3 transcription factor that activates the expression of multiple Th2 cytokines. Consistent with the idea that BCL-6 represses GATA-3 expression, we found that GATA-3 levels are up-regulated in BCL-6(-/-)STAT6(-/-) CD4 T cells compared with STAT6(-/-) CD4 T cells. Retrovirus-mediated expression of BCL-6 in BCL-6(-/-)STAT6(-/-) T cells as well as developing wild-type Th2 cells leads to a potent repression of IL-4 and IL-10 secretion. Retrovirus-mediated expression of BCL-6 in both BCL-6(-/-)STAT6(-/-) and wild-type T cells also leads to a significant decrease in GATA-3 protein levels. Surprisingly, BCL-6 does not appear to regulate GATA-3 mRNA levels and thus BCL-6 appears to regulate GATA-3 expression at a posttranscriptional level. Regulation of GATA-3 protein levels is likely a key mechanism for how BCL-6 regulates Th2 cytokine expression and Th2 differentiation independently of STAT6. These data also point to a novel regulatory mechanism for BCL-6 separate from transcriptional repression."xsd:string |
| http://purl.uniprot.org/citations/12594267 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.170.5.2435"xsd:string |
| http://purl.uniprot.org/citations/12594267 | http://purl.uniprot.org/core/author | "Sato H."xsd:string |
| http://purl.uniprot.org/citations/12594267 | http://purl.uniprot.org/core/author | "Dent A.L."xsd:string |
| http://purl.uniprot.org/citations/12594267 | http://purl.uniprot.org/core/author | "Kusam S."xsd:string |
| http://purl.uniprot.org/citations/12594267 | http://purl.uniprot.org/core/author | "Toney L.M."xsd:string |
| http://purl.uniprot.org/citations/12594267 | http://purl.uniprot.org/core/date | "2003"xsd:gYear |
| http://purl.uniprot.org/citations/12594267 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/12594267 | http://purl.uniprot.org/core/pages | "2435-2441"xsd:string |
| http://purl.uniprot.org/citations/12594267 | http://purl.uniprot.org/core/title | "Inhibition of Th2 differentiation and GATA-3 expression by BCL-6."xsd:string |
| http://purl.uniprot.org/citations/12594267 | http://purl.uniprot.org/core/volume | "170"xsd:string |
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